[HTML][HTML] Hemodynamics in Intracranial Aneurysm Formation

H Koseki - 2024 - intechopen.com
Intracranial aneurysms (IAs) are dilated lesions of the arterial wall caused by a dysfunction
of the hemodynamic stress, leading to subarachnoid hemorrhage, which can be devastating …

Role of hemodynamics in initiation/growth of intracranial aneurysms

MR Diagbouga, S Morel, P Bijlenga… - European journal of …, 2018 - Wiley Online Library
Background Intracranial aneurysm (IA) is a disease of the vascular wall resulting in
abnormal enlargement of the vessel lumen. It is a common pathology with a prevalence of …

Two diverse hemodynamic forces, a mechanical stretch and a high wall shear stress, determine intracranial aneurysm formation

H Koseki, H Miyata, S Shimo, N Ohno, K Mifune… - Translational Stroke …, 2020 - Springer
Intracranial aneurysm (IA) usually induced at a bifurcation site of intracranial arteries causes
a lethal subarachnoid hemorrhage. Currently, IA is considered as a macrophage-mediated …

Molecular basis for intracranial aneurysm formation

M Fukuda, T Aoki - Neurovascular Events After Subarachnoid Hemorrhage …, 2015 - Springer
Intracranial aneurysm (IA) is a socially important disease both because it has a high
prevalence and because of the severity of resultant subarachnoid hemorrhages after IA …

Novel methodologies for investigating the pathophysiology of cerebral aneurysms

Z Zeng - 2011 - search.proquest.com
An intracranial aneurysm (IA) is a pathological state of a cerebral artery in which the elastin
and smooth muscle cells found in the healthy arterial wall are absent. Rupture of an IA is a …

The biophysical role of hemodynamics in the pathogenesis of cerebral aneurysm formation and rupture

S Soldozy, P Norat, M Elsarrag, A Chatrath… - Neurosurgical …, 2019 - thejns.org
The pathogenesis of intracranial aneurysms remains complex and multifactorial. While
vascular, genetic, and epidemiological factors play a role, nascent aneurysm formation is …

High wall shear stress and positive wall shear stress gradient trigger the initiation of intracranial aneurysms

E Metaxa, M Tremmel, J Xiang… - Summer …, 2009 - asmedigitalcollection.asme.org
While the pathogenesis of an intracranial aneurysm (IA) is poorly understood, it has been
generally postulated to be related to hemodynamic insult. IAs are predominantly located at …

Chronic inflammation in intracranial aneurysm formation

T Aoki, M Fukuda, S Narumiya - Inflammation and Regeneration, 2013 - jstage.jst.go.jp
Intracranial aneurysm (IA) is a cerebrovascular disease usually affected the bifurcation sites
of intracranial arteries. IA is socially important because IA can develop a lethal subarachnoid …

Hemodynamic and histopathological changes in the early phase of the development of an intracranial aneurysm

H Kataoka, T Yagi, T Ikedo, H Imai… - Neurologia medico …, 2020 - jstage.jst.go.jp
Hemodynamic stress and chronic inflammation are closely associated with the pathogenesis
of intracranial aneurysms (IAs). However, the hemodynamic and biological mechanisms …

Shedding the light on the natural history of intracranial aneurysms: an updated overview

A Giotta Lucifero, M Baldoncini, N Bruno, R Galzio… - Medicina, 2021 - mdpi.com
The exact molecular pathways underlying the multifactorial natural history of intracranial
aneurysms (IAs) are still largely unknown, to the point that their understanding represents an …