In this study we compared methylation levels of 27,578 CpG sites between paired samples
of the tumor and surrounding liver tissues with various degrees of damage (fibrosis …

Objectives: Several studies revealed that the proportion of hepatocellular carcinoma (HCC)
without hepatitis virus infection (NBNC-HCC) is increasing. On the other hand, epigenetic …

Objective: To clarify the progression pattern of abnormal DNA methylation during the
development of hepatocellular carcinoma (HCC) using a comprehensive methylation assay …

Hepatocellular carcinoma (HCC) most commonly arises from chronic inflammation due to
viral infection, as a result of genetic and epigenetic abnormalities. A global picture of …

In this study we compared methylation levels of 27,578 CpG sites between paired samples
of the tumor and surrounding liver tissues with various degrees of damage (fibrosis …

Aberrant DNA methylation has been implicated in the development of hepatocellular
carcinoma (HCC). Our aim was to clarify its molecular mechanism and to identify useful …

Background and Aims Hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC)
progresses with a highly multicentric occurrence (MO) even after radical hepatectomy …

Methylation of promoter CpG islands has been associated with gene silencing and
demonstrated to lead to chromosomal instability. Therefore, some postulate that aberrantly …

Hepatocellular carcinoma (HCC) usually develops on the basis of chronic hepatitis and liver
cirrhosis, where inactivation of several tumor suppressor genes (TSGs) takes place via …

Simple Summary Hepatocellular carcinoma (HCC) remains a significant cause of cancer-
related deaths worldwide. Although most HCC cases have a background of cirrhosis, up to …