Despite much progress in regulations to improve paediatric drug development, there
remains a significant need to develop better medications for children. For the design of oral …

The complex process of oral drug absorption is influenced by a host of drug and formulation
properties as well as their interaction with the gastrointestinal environment in terms of drug …

Aim of the Review relatively new European Union regulations on children's medicines have
emphasised the need for scientists to consider paediatric populations during drug …

The dissolution, intestinal absorption and presystemic metabolism of a drug depend on its
physicochemical characteristics but also on numerous physiological (eg gastrointestinal pH …

Objectives In this review, the current biopharmaceutical approaches for evaluation of oral
formulation performance in paediatrics are discussed. Key findings The paediatric …

A thorough knowledge of the newborn (age, birth to 1 month postpartum) infant's
gastrointestinal tract (GIT) is critical to the evaluation of the absorption, distribution …

Purpose Compound solubility serves as a surrogate indicator of oral biopharmaceutical
performance. Between infancy and adulthood, marked compositional changes in …

The objective of this paper was to review existing information regarding food effects on drug
absorption within paediatric populations. Mechanisms that underpin food–drug interactions …

Introduction: A large proportion of prescribed drugs to children are administered orally. Age-
related change in factors affecting oral absorption can have consequences for drug dosing …

This mini-review discusses relevant aspects of gastro-intestinal transit in different ages of
paediatric patients with an attempt to highlight factors which should be considered in oral …