The specificity of DNMT1 for hemimethylated DNA is a central feature for the inheritance of
DNA methylation. We investigated this property in competitive methylation kinetics using …

Abstract DNA methyltransferase 1 (Dnmt1) has a central role in copying the pattern of DNA
methylation after replication which is one manifestation of epigenetic inheritance. With …

The DNTM3A and DNMT3B de novo DNA methyltransferases (DNMTs) are responsible for
setting genomic DNA methylation patterns, a key layer of epigenetic information. Here, using …

Background In mammals, epigenetic information is established and maintained via the
postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1 …

CpG methylation is involved in a wide range of biological processes in vertebrates as well
as in plants and fungi. To date, three enzymes, Dnmt1, Dnmt3a, and Dnmt3b, are known to …

DNA methyltransferases (DNMTs) play an important role in establishing and maintaining
DNA methylation. Aberrant expression of DNMTs and their isoforms has been found in many …

DNA methyltransferases (Dnmts) mediate the epigenetic modification of eukaryotic
genomes. Mammalian DNA methylation patterns are established and maintained by co …

Dnmt3a and Dnmt3b are two major de novo DNA methyltransferases essential for
embryonic development in mammals. It has been shown that Dnmt3a and Dnmt3b have …

Methylation of cytosine in DNA plays a crucial role in development through inheritable gene
silencing. The DNA methyltransferase Dnmt1 is responsible for the propagation of …

DNA methyltransferase Dnmt1 ensures clonal transmission of lineage-specific DNA
methylation patterns in a mammalian genome during replication. Dnmt1 is targeted to …