Despite four decades of research to support the association between DNA methylation and
gene expression, the causality of this relationship remains unresolved. Here, we reaffirm that …

In mammalian cells, DNA methylation critically regulates gene expression and thus has
pivotal roles in myriad of physiological and pathological processes. Here we report a novel …

Advances in sequencing technology allow researchers to map genome-wide changes in
DNA methylation in development and disease. However, there is a lack of experimental …

Epigenetic studies relied so far on correlations between epigenetic marks and gene
expression pattern. Technologies developed for epigenome editing now enable direct study …

Background Fusion of DNA methyltransferase domains to the nuclease-deficient clustered
regularly interspaced short palindromic repeat (CRISPR) associated protein 9 (dCas9) has …

Dear Editor, DNA methylation and demethylation play a critical role in regulating gene
expression as well as developmental and pathological processes 1. For example …

DNA hypermethylation at the promoter of tumour-suppressor genes is tightly correlated with
their transcriptional repression and recognized as the hallmark of majority of cancers …

In normal mammalian development cytosine methylation is essential and is directed to
specific regions of the genome. Despite notable advances through mapping its genome …

Background DNA methylation has widespread effects on gene expression during
development. However, our ability to assign specific function to regions of DNA methylation …

Despite the increased interest in epigenetic research, its progress has been hampered by a
lack of satisfactory tools to control epigenetic factors in specific genomic regions. Until now …