Noncoding RNAs at H19/IGF2 Locus: Role in Imprinting, Gene Expression, and Associated Pathologies

N Berteaux, N Spruyt, E Adriaenssens - RNA Technologies and Their …, 2010 - Springer
Genomic imprinting is a form of epigenetic regulation whereby some genes are silenced
according to their parental origin. The H19/IGF2 locus located in the chromosome 11 in p15 …

The Increasing Complexity of the Oncofetal H19 Gene Locus: Functional Dissection and Therapeutic Intervention

I Matouk, E Raveh, P Ohana, RA Lail… - International journal of …, 2013 - mdpi.com
The field of the long non-coding RNA (lncRNA) is advancing rapidly. Currently, it is one of
the most popular fields in the biological and medical sciences. It is becoming increasingly …

[HTML][HTML] Role of long non-coding RNA in cells: Example of the H19/IGF2 locus

C Vennin, F Dahmani, N Spruyt, E Adriaenssens - 2013 - scirp.org
In the past decade, studies of non-coding RNAs increase. Non-coding RNAs are divided in
two classes: small and long non-coding RNA. It was shown that long non-coding RNAs …

The H19 locus: Role of an imprinted non‐coding RNA in growth and development

A Gabory, H Jammes, L Dandolo - Bioessays, 2010 - Wiley Online Library
The H19 gene produces a non‐coding RNA, which is abundantly expressed during
embryonic development and down‐regulated after birth. Although this gene was discovered …

Intragenic micro RNA and long non-coding RNA: novel potential regulator of IGF 2-H 19 imprinting region.

N Ma, L Zhou, Y Zhang, Y Jiang… - Evolution & …, 2014 - search.ebscohost.com
The authors discuss some of the potential regulators of the IGF2-H19 region and several
advances in molecular biology. The author mentions the study of Bartel in 2004 where they …

H19 acts as a trans regulator of the imprinted gene network controlling growth in mice

A Gabory, MA Ripoche, A Le Digarcher… - …, 2009 - journals.biologists.com
The imprinted H19 gene produces a non-coding RNA of unknown function. Mice lacking
H19 show an overgrowth phenotype, due to a cis effect of the H19 locus on the adjacent Igf2 …

Towards unravelling the Igf2/H19 imprinted domain

S Viville, MA Surani - Bioessays, 1995 - Wiley Online Library
Genomic imprinting is an epigenetic marking process that confers parent‐of‐origin‐
dependent expression on certain genes. These imprinted genes are sometimes found in …

H19 Antisense RNA Can Up-Regulate Igf2 Transcription by Activation of a Novel Promoter in Mouse Myoblasts

VG Tran, F Court, A Duputie, E Antoine, N Aptel… - PLoS …, 2012 - journals.plos.org
It was recently shown that a long non-coding RNA (lncRNA), that we named the 91H RNA
(ie antisense H19 transcript), is overexpressed in human breast tumours and contributes in …

A novel H19 antisense RNA overexpressed in breast cancer contributes to paternal IGF2 expression

N Berteaux, N Aptel, G Cathala, C Genton… - … and cellular biology, 2008 - Am Soc Microbiol
The H19/IGFf2 locus belongs to a large imprinted domain located on human chromosome
11p15. 5 (homologue to mouse distal chromosome 7). The H19 gene is expressed from the …

The long non-coding RNA 91H increases aggressive phenotype of breast cancer cells and up-regulates H19/IGF2 expression through epigenetic modifications

C Vennin, N Spruyt, YM Robin, T Chassat… - Cancer letters, 2017 - Elsevier
Numerous genomic imprinting loci are regulated by long non-coding RNA (lncRNA). We
have previously identified a new lncRNA at the H19/IGF2 locus transcribed in H19 antisense …