Epigenetic alterations, such as promoter hypermethylation, may drive cancer through tumor
suppressor gene inactivation. However, we have limited ability to differentiate driver DNA …

Cancer cells typically exhibit aberrant DNA methylation patterns that can drive malignant
transformation. Whether cancer cells are dependent on these abnormal epigenetic …

Aberrant DNA methylation is considered to be one of the most common hallmarks of cancer.
Several recent advances in assessing the DNA methylome provide great promise for …

Accumulating evidence has demonstrated that transcriptional regulation is affected by DNA
methylation. Understanding the perturbation of DNA methylation-mediated regulation …

Background One of the most important recent findings in cancer genomics is the
identification of novel driver mutations which often target genes that regulate genome-wide …

Background In cancer, mutations of DNA methylation modification genes have crucial roles
for epigenetic modifications genome-wide, which lead to the activation or suppression of …

Aberrant DNA methylation plays an important role in cancer progression. However, no
resource has been available that comprehensively provides DNA methylation-based …

Background There is growing evidence that DNA methylation alterations contribute to
carcinogenesis. While cancer tissue exhibits widespread DNA methylation changes, the …

The discovery of cancer-associated alterations has primarily focused on genetic variants.
Nonetheless, altered epigenomes contribute to deregulate transcription and promote …

Background Aberrant DNA methylation is a hallmark of cancer cells. However, the
mechanisms underlying changes in DNA methylation remain elusive. Transcription factors …