Genomics, convergent neuroscience and progress in understanding autism spectrum disorder

HR Willsey, AJ Willsey, B Wang… - Nature Reviews …, 2022 - nature.com
More than a hundred genes have been identified that, when disrupted, impart large risk for
autism spectrum disorder (ASD). Current knowledge about the encoded proteins—although …

Autism spectrum disorders: from genes to neurobiology

AJ Willsey, MW State - Current opinion in neurobiology, 2015 - Elsevier
Highlights•High throughput genomic methods are rapidly increasing the pool of ASD
genes.•Heterogeneity, pleiotropy, and brain complexity complicate translation to …

[HTML][HTML] Genetic architecture of autism spectrum disorder: Lessons from large-scale genomic studies

L Choi, JY An - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a strong genetic
component. Recently developed genomic technologies, including microarray and next …

Genetic heterogeneity in autism: From single gene to a pathway perspective

JY An, C Claudianos - Neuroscience & Biobehavioral Reviews, 2016 - Elsevier
The extreme genetic heterogeneity of autism spectrum disorder (ASD) represents a major
challenge. Recent advances in genetic screening and systems biology approaches have …

Progress in the genetics of autism spectrum disorder

M Woodbury‐Smith, SW Scherer - Developmental Medicine & …, 2018 - Wiley Online Library
A genetic basis for autism spectrum disorder (ASD) is now well established, and with the
availability of high‐throughput microarray and sequencing platforms, major advances have …

Genetic contributions to autism spectrum disorder

A Havdahl, M Niarchou, A Starnawska… - Psychological …, 2021 - cambridge.org
Autism spectrum disorder (autism) is a heterogeneous group of neurodevelopmental
conditions characterized by early childhood-onset impairments in communication and social …

[HTML][HTML] Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism

NN Parikshak, R Luo, A Zhang, H Won, JK Lowe… - Cell, 2013 - cell.com
Genetic studies have identified dozens of autism spectrum disorder (ASD) susceptibility
genes, raising two critical questions:(1) do these genetic loci converge on specific biological …

Genetics and genomics of autism spectrum disorder: embracing complexity

S De Rubeis, JD Buxbaum - Human molecular genetics, 2015 - academic.oup.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) characterized by
impairments in social communication and social interaction and the presence of repetitive …

Risk factors for autism: translating genomic discoveries into diagnostics

SW Scherer, G Dawson - Human genetics, 2011 - Springer
Autism spectrum disorders (ASDs) are a group of conditions characterized by impairments in
communication and reciprocal social interaction, and the presence of restricted and …

The conundrums of understanding genetic risks for autism spectrum disorders

MW State, P Levitt - Nature neuroscience, 2011 - nature.com
Recent advances in the genetics of autism spectrum disorders (ASDs) are offering new
valuable insights into molecular and cellular mechanisms of pathology. At the same time, the …