The microtubule-targeting paclitaxel (PTX) and docetaxel (DTX) are widely used
chemotherapeutic agents. However, the dysregulation of apoptotic processes, microtubule …

To address the problem of resistance to paclitaxel treatment, we have investigated to which
extent is possible to predict Breast Cancer (BC) patient response to this drug. We carried out …

Purpose: Paclitaxel is used in the treatment of solid tumors and displays high interindividual
variation in exposure. Low paclitaxel clearance could lead to increased toxicity during …

Background: Paclitaxel and docetaxel affect microtubule polymerization, yet surprising
differences in tumor sensitivity to the taxanes have been observed. Docetaxel was superior …

The goal of the present study was to define gene expression signatures that predict a
chemosensitivity of non-small cell lung cancer (NSCLC) to cisplatin and paclitaxel. To …

Purpose Paclitaxel is a commonly used chemotherapy drug with substantial variability in
pharmacokinetics (PK) that affects treatment efficacy and toxicity. Pharmacometabolomic …

Background: The differential sensitivity of some tumors to paclitaxel and docetaxel raises
questions regarding the specific mechanisms responsible for the discrepant sensitivity to …

Model‐based meta‐analysis of dose response is a sophisticated method to guide dose and
regimen selection. In this report, the effects of paclitaxel dose and regimen (weekly or every …

Increasingly, the effectiveness of adjuvant chemotherapy agents for breast cancer has been
related to changes in the genomic profile of tumors. We investigated correspondence …

Purpose This study was conducted to develop and validate an individualized prediction
model for automated detection of acquired taxane resistance (ATR). Materials and Methods …