Pluripotent stem cells evade replicative senescence, whereas other primary cells lose their
proliferation and differentiation potential after a limited number of cell divisions, and this is …

Cells in culture undergo replicative senescence. In this study, we analyzed functional,
genetic and epigenetic sequels of long-term culture in human mesenchymal stem cells …

Within 2–3 months of in vitro culture‐expansion, mesenchymal stromal cells (MSC) undergo
replicative senescence characterized by cell enlargement, loss of differentiation potential …

Telomere shortening is associated with organismal aging. iPS cells have been recently
derived from old patients; however, it is not known whether telomere chromatin acquires the …

The discovery that somatic cells can be induced into a pluripotent state by the expression of
reprogramming factors has enormous potential for therapeutics and human disease …

Aim: To determine whether transcriptional reprogramming is capable of reversing the
developmental aging of normal human somatic cells to an embryonic state. Materials & …

Human bone marrow mesenchymal stem cells (MSCs) expanded in vitro exhibit not only a
tendency to lose their proliferative potential, homing ability and telomere length but also …

Induced pluripotent stem cells (iPSCs) offer immense potential for regenerative medicine
and studies of disease and development. Somatic cell reprogramming involves epigenomic …

In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in
repressive histone post-translational modifications. However, the chromatin marks …

Replicative senescence of cells in vitro is often considered as counterpart for aging of the
organism in vivo. In fact, both processes are associated with functional decay and similar …