Determination of serum urea by isotope dilution mass spectrometry as a candidate definitive method

MJ Welch, A Cohen, HS Hertz, FC Ruegg… - Analytical …, 1984 - ACS Publications
An Isotope dilution mass spectrometrlc (ID/MS) method for serum urea Is described. The
method utilizes urea-180 as the labeled Internal standard and Involves Isolation of urea from …

Determination of serum uric acid by isotope dilution mass spectrometry as a new candidate definitive method

P Ellerbe, A Cohen, MJ Welch, EV White - Analytical chemistry, 1990 - ACS Publications
A new Isotope dilution mass spectrometrlc method for uric acid Is described. A known weight
of [1, 3-1sN2] urlc acid Is added to a known weight of serum, and the mixture Is allowed to …

Measurement of urea in human serum by isotope dilution mass spectrometry: a reference procedure

A Kessler, L Siekmann - Clinical Chemistry, 1999 - academic.oup.com
Background: A reference measurement procedure is needed to demonstrate the traceability
of results of urea measurements in human serum. We developed a measurement procedure …

Gas chromatography/mass spectrometric determination of [15N] urea in plasma and application to urea metabolism study

KY Tserng, SC Kalhan - Analytical Chemistry, 1982 - ACS Publications
The study of urea metabolism In humans necessitates sen-sitive methods, so that very low
Isotopic enrichments of plasma or urinary urea can be measured. A stable derivative of urea …

Determination of uric acid in human serum by isotope dilution-mass spectrometry. Definitive methods in clinical chemistry, III

L Siekmann - 1985 - degruyter.com
A method for the measurement of uric acid in human serum by isotope dilution-mass
spectrometry is described. The analytical procedure consists of the following Steps:(1) …

Assay of stable isotope labelled urea in biological fluids by selected ion monitoring

JE Nelson, TI Ruo - Clinica chimica acta, 1988 - Elsevier
A selected ion-monitoring method, incorporating an internal standard, was developed to
allow the direct and simultaneous measurement of stable isotopelabelled urea and …

Calibration for isotope dilution mass spectrometry—description of an alternative to the bracketing procedure

LM Thienpont, B Van Nieuwenhove… - Journal of mass …, 1996 - Wiley Online Library
A calibration method for isotope dilution mass spectrometry is presented that fully accounts
for non‐linearity of calibration functions, caused by the interference of the analyte on the m/z …

Determination of serum urea by mass fragmentography

I Björkhem, R Blomstrand, G Öhman - Clinica Chimica Acta, 1976 - Elsevier
A mass fragmentographic method of high accuracy for determination of serum urea is
described. A fixed amount of [15N 2] urea is added to a fixed amount of serum, then the urea …

Specific method for determining uric acid in serum using high-performance liquid chromatography and gas chromatography-mass spectrometry

CK Lim, DE Pryde, AM Lawson - Journal of Chromatography A, 1978 - Elsevier
A method using a combination of high-performance liquid chromatography and stable-
isotope dilution-mass spectrometry is described for the specific quantitation of uric acid in …

GC-MS determination of ratios of stable-isotope labelled to natural urea using [13C15N2] urea for studying urea kinetics in serum and as a means to validate routine …

BG Wolthers, T Tepper, A Withag, GT Nagel… - Clinica chimica acta, 1994 - Elsevier
Abstract A GC-MS determination of urea in serum or spent dialysate is described, using 13 C
15 N 2-labelled urea and assaying the area ratio of labelled to natural urea by mass …