Epigenetic prediction of complex traits and death
Background Genome-wide DNA methylation (DNAm) profiling has allowed for the
development of molecular predictors for a multitude of traits and diseases. Such predictors …
development of molecular predictors for a multitude of traits and diseases. Such predictors …
DNA methylation-based predictors of health: applications and statistical considerations
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …
development, because, unlike static genetic risk estimates, DNA methylation varies …
The potential of DNA methylation as a biomarker for obesity and smoking
A Heikkinen, S Bollepalli… - Journal of internal …, 2022 - Wiley Online Library
DNA methylation is an epigenetic modification that has consistently been shown to be linked
with a variety of human traits and diseases. Because DNA methylation is dynamic and …
with a variety of human traits and diseases. Because DNA methylation is dynamic and …
DNA methylation signatures in peripheral blood strongly predict all-cause mortality
Y Zhang, R Wilson, J Heiss, LP Breitling… - Nature …, 2017 - nature.com
DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we
performed epigenome-wide screening and validation to identify mortality-related DNAm …
performed epigenome-wide screening and validation to identify mortality-related DNAm …
DNA methylation age of blood predicts all-cause mortality in later life
Background DNA methylation levels change with age. Recent studies have identified
biomarkers of chronological age based on DNA methylation levels. It is not yet known …
biomarkers of chronological age based on DNA methylation levels. It is not yet known …
Refining epigenetic prediction of chronological and biological age
Background Epigenetic clocks can track both chronological age (cAge) and biological age
(bAge). The latter is typically defined by physiological biomarkers and risk of adverse health …
(bAge). The latter is typically defined by physiological biomarkers and risk of adverse health …
Personalized epigenomic signatures that are stable over time and covary with body mass index
The epigenome consists of non–sequence-based modifications, such as DNA methylation,
that are heritable during cell division and that may affect normal phenotypes and …
that are heritable during cell division and that may affect normal phenotypes and …
Race-specific alterations in DNA methylation among middle-aged African Americans and Whites with metabolic syndrome
Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors for all-cause mortality,
cardiovascular disease, and cancer. Identifying epigenetic alterations associated with MetS …
cardiovascular disease, and cancer. Identifying epigenetic alterations associated with MetS …
The association of DNA methylation with body mass index: distinguishing between predictors and biomarkers
Background DNA methylation is associated with body mass index (BMI), but it is not clear if
methylation scores are biomarkers for extant BMI or predictive of future BMI. Here, we …
methylation scores are biomarkers for extant BMI or predictive of future BMI. Here, we …
Epigenome-wide association studies: current knowledge, strategies and recommendations
The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …
between genetic and environmental factors. The variability in risk and outcomes in these …