Drug resistance is a significant concern in the treatment of diseases, including
cryptococcosis caused by Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga) …

The Prp8 intein is one of the most widespread eukaryotic inteins, present in important
pathogenic fungi, including Cryptococcus and Aspergillus species. Because the processed …

Self-splicing proteins, called inteins, are present in many human pathogens, including the
emerging fungal threats Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga), the …

Inteins are self-splicing intervening sequences in proteins, and inteins of pathogenic
organisms can be attractive drug targets. Here, we report an intein in important fungal …

Multidrug-resistant pathogens are of significant concern in recent years. Hence new
antifungal and anti-bacterial drug targets are urgently needed before the situation goes …

Protein splicing is a post-translational process by which an intervening polypeptide, or
intein, catalyzes its own removal from the flanking polypeptides, or exteins, concomitant with …

We have used comparative sequence analysis to identify an intein‐like sequence (protein
splicing element) present in Cryptococcus neoformans, a fungal pathogen of humans. The …

Mycobacterium tuberculosis harbors three protein splicing elements, called inteins, in critical
genes and their protein products. Post-translational removal of the inteins occurs …

As the Cne PRP8 intein is active and exists in an essential gene of an important fungal
pathogen, inhibitors of splicing and assays for intein activity are of interest. The self-splicing …

Cryptococcus neoformans is a major etiological agent of fungal meningoencephalitis. The
outcome of cryptococcosis depends on the complex interactions between the pathogenic …