Dexmedetomidine is an α 2-adrenoceptor agonist with sedative, anxiolytic, sympatholytic,
and analgesic-sparing effects, and minimal depression of respiratory function. It is potent …

Dexmedetomidine is a potent and highly selective α2-adrenoceptor agonist with a selectivity
ratio of 1600: 1 (α2: α1). Dexmedetomidine is a highly lipophylic agent that is rapidly …

Objective: To characterize the pharmacokinetics of dexmedetomidine and monitor any
dexmedetomidine-related adverse events in postoperative pediatric patients requiring short …

Dexmedetomidine, a highly selective α2‐adrenoceptor agonist, reduces the requirements
for anesthetic, analgesic, sedative, and hypnotic drugs. Dexmedetomidine pharmacokinetics …

Background: Published dexmedetomidine pharmacokinetic studies in children are limited by
participant numbers and restricted pathology. Pooling the available studies allows …

Objective: To evaluate recent comparative studies regarding the safety and efficacy of
dexmedetomidine in adults. Data Sources: Articles evaluating safety and efficacy of …

Background To investigate dexmedetomidine in children, the authors performed an open-
label study of the pharmacokinetics and pharmacodynamics of dexmedetomidine. Methods …

BACKGROUND: Dexmedetomidine is a highly selective α 2-agonist with hypnotic,
analgesic, and anxiolytic properties. Despite off-label administration, dexmedetomidine has …

Abstract▴ Dexmedetomidine is a potent α 2-adrenoceptor agonist with 8 times higher affinity
for the α 2-adrenoceptorthan clonidine.▴ Dexmedetomidine has shown sedative, analgesic …

Dexmedetomidine, an α 2-adrenergic agonist with sedative and analgesic properties, is
mainly cleared by hepatic metabolism. Because the pharmacokinetics of dexmedetomidine …