[HTML][HTML] Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation
Background DNA methylation (DNAm) is a critical regulator of both development and
cellular identity and shows unique patterns in neurons. To better characterize maturational …
cellular identity and shows unique patterns in neurons. To better characterize maturational …
Neuronal activity modifies the DNA methylation landscape in the adult brain
DNA methylation has been traditionally viewed as a highly stable epigenetic mark in
postmitotic cells. However, postnatal brains appear to show stimulus-induced methylation …
postmitotic cells. However, postnatal brains appear to show stimulus-induced methylation …
[HTML][HTML] Genome-wide divergence of DNA methylation marks in cerebral and cerebellar cortices
Y Xin, B Chanrion, MM Liu, H Galfalvy, R Costa… - PloS one, 2010 - journals.plos.org
Background Emerging evidence suggests that DNA methylation plays an expansive role in
the central nervous system (CNS). Large-scale whole genome DNA methylation profiling of …
the central nervous system (CNS). Large-scale whole genome DNA methylation profiling of …
Role of CpG context and content in evolutionary signatures of brain DNA methylation
Y Xin, AH O'Donnell, Y Ge, B Chanrion, M Milekic… - Epigenetics, 2011 - Taylor & Francis
DNA methylation is essential in brain function and behavior; therefore, understanding the
role of DNA methylation in brain-based disorders begins with the study of DNA methylation …
role of DNA methylation in brain-based disorders begins with the study of DNA methylation …
[HTML][HTML] Human brain region-specific variably methylated regions are enriched for heritability of distinct neuropsychiatric traits
LF Rizzardi, PF Hickey, A Idrizi, R Tryggvadóttir… - Genome biology, 2021 - Springer
Background DNA methylation dynamics in the brain are associated with normal
development and neuropsychiatric disease and differ across functionally distinct brain …
development and neuropsychiatric disease and differ across functionally distinct brain …
Global epigenomic reconfiguration during mammalian brain development
Introduction Several lines of evidence point to a key role for dynamic epigenetic changes
during brain development, maturation, and learning. DNA methylation (mC) is a stable …
during brain development, maturation, and learning. DNA methylation (mC) is a stable …
Methylomic trajectories across human fetal brain development
Epigenetic processes play a key role in orchestrating transcriptional regulation during
development. The importance of DNA methylation in fetal brain development is highlighted …
development. The importance of DNA methylation in fetal brain development is highlighted …
Emerging insights into the distinctive neuronal methylome
AW Clemens, HW Gabel - Trends in Genetics, 2020 - cell.com
The genomes of mammalian neurons are enriched for unique forms of DNA methylation,
including exceptionally high levels of non-CG methylation. Here, we review recent studies …
including exceptionally high levels of non-CG methylation. Here, we review recent studies …
[HTML][HTML] Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …
maintaining cellular phenotype during differentiation, but little is known about the normal …
[HTML][HTML] Single-cell DNA methylome and 3D multi-omic atlas of the adult mouse brain
Cytosine DNA methylation is essential in brain development and is implicated in various
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …