Snail/PRMT5/NuRD complex contributes to DNA hypermethylation in cervical cancer by TET1 inhibition
J Gao, R Liu, D Feng, W Huang, M Huo… - Cell Death & …, 2021 - nature.com
The biological function of PRMT5 remains poorly understood in cervical cancer metastasis.
Here, we report that PRMT5 physically associates with the transcription factor Snail and the …
Here, we report that PRMT5 physically associates with the transcription factor Snail and the …
Epigenetic silencing of PTPRR activates MAPK signaling, promotes metastasis and serves as a biomarker of invasive cervical cancer
Epigenetic modifications are a driving force in carcinogenesis. However, their role in cancer
metastasis remains poorly understood. The present study investigated the role of DNA …
metastasis remains poorly understood. The present study investigated the role of DNA …
[HTML][HTML] PRMT5 disruption drives antitumor immunity in cervical cancer by reprogramming T cell-mediated response and regulating PD-L1 expression
Y Jiang, Y Yuan, M Chen, S Li, J Bai, Y Zhang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Protein arginine methyltransferase 5 (PRMT5) is an oncogene that promotes
tumor cell proliferation, invasion and metastasis. However, the underlying mechanisms by …
tumor cell proliferation, invasion and metastasis. However, the underlying mechanisms by …
[HTML][HTML] PRMT5 functionally associates with EZH2 to promote colorectal cancer progression through epigenetically repressing CDKN2B expression
L Yang, D Ma, Y Cao, D Li, X Zhou, J Feng, J Bao - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Protein arginine methyltransferase 5 (PRMT5) is a type II arginine
methyltransferase that symmetrically di-methylates arginine residues on both histone and …
methyltransferase that symmetrically di-methylates arginine residues on both histone and …
PRMT7 induces epithelial-to-mesenchymal transition and promotes metastasis in breast cancer
R Yao, H Jiang, Y Ma, L Wang, L Wang, J Du, P Hou… - Cancer research, 2014 - AACR
Epithelial-to-mesenchymal transition (EMT) enables metastasis. E-cadherin loss is a
hallmark of EMT, but there remains an incomplete understanding of the epigenetics of this …
hallmark of EMT, but there remains an incomplete understanding of the epigenetics of this …
DNMT1 maintains the methylation of miR‐152‐3p to regulate TMSB10 expression, thereby affecting the biological characteristics of colorectal cancer cells
C Wang, X Ma, J Zhang, X Jia, M Huang - IUBMB life, 2020 - Wiley Online Library
Objective DNA methyltransferases (DNMTs) take on a relevant role in epigenetic control of
cancer proliferation and cell survival. However, the molecular mechanisms underlying the …
cancer proliferation and cell survival. However, the molecular mechanisms underlying the …
A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression
H Chen, B Lorton, V Gupta, D Shechter - Oncogene, 2017 - nature.com
Abstract Protein arginine methyltransferase 5 (PRMT5) complexed with MEP50/WDR77
catalyzes arginine methylation on histones and other proteins. PRMT5-MEP50 activity is …
catalyzes arginine methylation on histones and other proteins. PRMT5-MEP50 activity is …
PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B
J Wang, Z Xiao, P Li, C Wu, Y Li, Q Wang, Y Chen… - Oncogene, 2023 - nature.com
PRMT6, a type I arginine methyltransferase, di-methylates the arginine residues of both
histones and non-histones asymmetrically. Increasing evidence indicates that PRMT6 plays …
histones and non-histones asymmetrically. Increasing evidence indicates that PRMT6 plays …
Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/β-catenin and AKT/GSK3β proliferative signaling
J Chung, V Karkhanis, RA Baiocchi, S Sif - Journal of Biological Chemistry, 2019 - ASBMB
Epigenetic regulation by the type II protein arginine methyltransferase, PRMT5, plays an
essential role in the control of cancer cell proliferation and tumorigenesis. In this report, we …
essential role in the control of cancer cell proliferation and tumorigenesis. In this report, we …
miR‐26a‐5p Suppresses Wnt/β‐Catenin Signaling Pathway by Inhibiting DNMT3A‐Mediated SFRP1 Methylation and Inhibits Cancer Stem Cell‐Like Properties of …
J Yu, Z Ge, S Chen, S Li, X Zhang, J Hu… - Disease …, 2022 - Wiley Online Library
Background. Lung cancer is a malignant cancer which results in the most cancer incidence
and mortality worldwide. There is increasing evidence that the pattern of DNA methylation …
and mortality worldwide. There is increasing evidence that the pattern of DNA methylation …