[HTML][HTML] Microfibrillar-associated protein 4 in health and disease

R Kanaan, M Medlej-Hashim, R Jounblat, B Pilecki… - Matrix Biology, 2022 - Elsevier
Abstract Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein
belonging to the fibrinogen-related domain family. It has been localized to elastic fiber-rich …

Localization of microfibrillar-associated protein 4 (MFAP4) in human tissues: clinical evaluation of serum MFAP4 and its association with various cardiovascular …

H Wulf-Johansson, S Lock Johansson, A Schlosser… - PloS one, 2013 - journals.plos.org
Microfibrillar-associated protein 4 (MFAP4) is located in the extracellular matrix (ECM). We
sought to identify tissues with high levels of MFAP4 mRNA and MFAP4 protein expression …

Molecular structure and function of microfibrillar‐associated proteins in skeletal and metabolic disorders and cancers

S Zhu, L Ye, S Bennett, H Xu, D He… - Journal of cellular …, 2021 - Wiley Online Library
Microfibrillar‐associated proteins (MFAPs) are extracellular matrix glycoproteins, which play
a role in microfibril assembly, elastinogenesis, and tissue homeostasis. MFAPs consist of …

Characterization of spontaneous air space enlargement in mice lacking microfibrillar-associated protein 4

AT Holm, H Wulf-Johansson… - … of Physiology-Lung …, 2015 - journals.physiology.org
Microfibrillar-associated protein 4 (MFAP4) is localized to elastic fibers in blood vessels and
the interalveolar septa of the lungs and is further present in bronchoalveolar lavage. Mfap4 …

MFAP4: a candidate biomarker for hepatic and pulmonary fibrosis?

C Mölleken, G Poschmann, F Bonella… - … Vasculitis, and Diffuse …, 2016 - europepmc.org
Background Several comparable mechanisms have been identified for hepatic and
pulmonary fibrosis. The human microfibrillar associated glycoprotein 4 (MFAP4), produced …

Microfibrillar-associated protein 4 regulates stress-induced cardiac remodeling

LE Dorn, W Lawrence, JM Petrosino, X Xu… - Circulation …, 2021 - Am Heart Assoc
Rationale: Cardiac hypertrophy, a major risk factor for heart failure, occurs when
cardiomyocytes remodel in response to complex signaling induced by injury or cell stress …

MFAP2 promotes epithelial–mesenchymal transition in gastric cancer cells by activating TGF-β/SMAD2/3 signaling pathway

JK Wang, WJ Wang, HY Cai, BB Du, P Mai… - OncoTargets and …, 2018 - Taylor & Francis
Introduction Microfibril-associated protein 2 (MFAP2) is an extracellular matrix protein that
interacts with fibrillin to modulate the function of microfibrils. MFAP2 has been reported to …

MFAP5 promotes tumor progression and bone metastasis by regulating ERK/MMP signaling pathways in breast cancer

Z Wu, T Wang, M Fang, W Huang, Z Sun, J Xiao… - Biochemical and …, 2018 - Elsevier
Breast cancer accounts for about 30% of all cancers in women, while approximately 70%
breast cancer patients developed bone metastases throughout the course of their disease …

MFAP5 suppression inhibits migration/invasion, regulates cell cycle and induces apoptosis via promoting ROS production in cervical cancer

Q Li, Y Zhang, Q Jiang - Biochemical and biophysical research …, 2018 - Elsevier
Cervical cancer is one of the most lethal types of cancer among female. Microfibrillar-
associated protein 5 (MFAP5) is an extracellular matrix (ECM) glycoprotein, and is confirmed …

Integrated analysis of microfibrillar-associated proteins reveals MFAP4 as a novel biomarker in human cancers

J Yang, H Song, L Chen, K Cao, Y Zhang, Y Li… - …, 2019 - Taylor & Francis
Aim: The potential functions and underlying mechanism of microfibrillar-associated proteins
(MFAPs) are explored in human cancers. Materials & methods: Here, we examined the …