Innovations in ultrasensitive and single-cell measurements enable us to study layers of
genome regulation in view of cellular and regulatory heterogeneity. Genome-scale mapping …

Epigenetic information in the mammalian oocyte has the potential to be transmitted to the
next generation and influence gene expression; this occurs naturally in the case of imprinted …

A systematic study of mouse oocytes using genome-wide chromatin immunoprecipitation
followed by sequencing (ChIP–seq) has revealed that dynamic histone modification events …

The mammalian genome experiences profound setting and resetting of epigenetic patterns
during the life-course. This is understood best for DNA methylation: the specification of germ …

BACKGROUND Over the past few years, advances in molecular technologies have allowed
unprecedented mapping of epigenetic modifications in gametes and during early embryonic …

Epigenetic modifications acquired during oocyte growth are essential for transcriptional
regulation, establishment of maternal DNA methylation imprints, and the maintenance of …

Background Gametogenesis in mammals entails profound re-patterning of the epigenome.
In the female germline, DNA methylation is acquired late in oogenesis from an essentially …

Erasure and subsequent reinstatement of DNA methylation in the germline, especially at
imprinted CpG islands (CGIs), is crucial to embryogenesis in mammals. The mechanisms …

Epigenetic regulation is complex, integrating transcriptional states of chromatin together with
structural information influencing function and genome integrity. Some of these modifications …

Background Previously, a role was demonstrated for transcription in the acquisition of DNA
methylation at imprinted control regions in oocytes. Definition of the oocyte DNA methylome …