Ascent to high-altitude elicits compensatory physiological adaptations in order to improve
oxygenation throughout the body. The brain is particularly vulnerable to the hypoxemia of …

New Findings What is the central question of this study? Hypoxia associated with ascent to
high altitude may threaten cerebral oxygen delivery. We sought to determine whether there …

The regulation of cerebral blood flow (CBF) is a complex process that is altered significantly
with altitude exposure. Acute exposure produces a marked increase in CBF, in proportion to …

Analysis of a paper by Severinghaus et al.(see text) has already shown that sea level
oxygen delivery (Dao2) is sustained 8 h after ascent to 3810 m, despite low arterial oxygen …

Abstract Ainslie, Philip N., and Andrew W. Subudhi. Invited Review: Cerebral blood flow at
high altitude. High Alt Med Biol. 15: 133–140, 2014.—This brief review traces the last 50 …

Non‐technical summary Brain blood flow increases during the first week of living at high
altitude. We do not understand completely what causes the increase or how the factors that …

The interindividual variation in ventilatory acclimatization to high altitude is likely reflected in
variability in the cerebrovascular responses to high altitude, particularly between brain …

The effects of partial acclimatization to high altitude (HA; 5,050 m) on cerebral metabolism
and cerebrovascular function have not been characterized. We hypothesized (1) increased …

During acclimatization to moderate altitudes, a simple calculation from data of others shows
that the rise in cerebral blood flow (CBF) is sufficient that oxygen delivery to brain (DaO2) is …

New Findings What is the topic of this review? Cerebrovascular reactivity to CO2, which is a
principal factor in determining ventilatory responses to CO2 through the role reactivity plays …