Context Circulating concentrations of free triiodothyronine (fT3), free thyroxine (fT4), and
thyrotropin (TSH) are partly heritable traits. Recent studies have advanced knowledge of …

Background: Thyroid hormones play a key role in differentiation and metabolism and are
known regulators of gene expression through both genomic and epigenetic processes …

Thyroid hormone is essential for normal metabolism and development, and overt
abnormalities in thyroid function lead to common endocrine disorders affecting …

Objective Minor variation in serum thyroid hormone (TH) levels can have important effects
on various clinical endpoints. Although 45–65% of the inter-individual variation in serum TH …

Background: The thyroid plays a key role in development and homeostasis, but it has been
difficult to establish causality with diseases and phenotypic traits because of several …

Purpose Thyroid hormones are essential for the normal function of almost all human tissues,
and have critical roles in metabolism, differentiation and growth. Free triiodothyronine (fT3) …

Objective While most of the variation in thyroid function is determined by genetic factors,
single nucleotide polymorphisms (SNPs) identified via genome-wide association analyses …

To date only a fraction of the genetic footprint of thyroid function has been clarified. We
report a genome-wide association study meta-analysis of thyroid function in up to 271,040 …

Context Autoimmune thyroid disease (AITD) includes Graves disease (GD) and Hashimoto
disease (HD), which often run in the same family. AITD etiology is incompletely understood …

Normal thyroid function is essential for health, but its genetic architecture remains poorly
understood. Here, for the heritable thyroid traits thyrotropin (TSH) and free thyroxine (FT4) …