Regenerating human islet organoids from stem cells remains a significant challenge
because of our limited knowledge on cues essential for developing the endocrine organoids …

In pancreatic tissue engineering, generating human pancreatic islet organoids from stem
cells has been challenging due mainly to a poor understanding of niches required for …

A 3D microenvironment is known to endorse pancreatic islet development from human
induced pluripotent stem cells (iPSCs). However, oxygen supply becomes a limiting factor in …

Human pluripotent stem cell (hPSC)-derived islet cells provide promising resources for
diabetes studies, cell replacement treatment and drug screening. Recently, hPSC-derived …

Diabetes is an emerging global epidemic that affects more that 285 million people
worldwide. Engineering of endocrine pancreas tissue holds great promise for the future of …

Insulin secretion is elaborately modulated in pancreatic ß cells within islets of three-
dimensional (3D) structures. Using human pluripotent stem cells (hPSCs) to develop islet …

Diabetes is one of the leading causes of death globally. Currently, the donor pancreas is the
only source of human islets, placing extreme constraints on supply. Hence, it is imperative to …

Organoids, which exhibit spontaneous organ specific organization, function, and multi-
cellular complexity, are in essence the in vitro reproduction of specific in vivo organ systems …

Islet transplantation is a promising treatment for type 1 diabetes. However, treatment failure
can result from loss of functional cells associated with cell dispersion, low viability, and …

Organoids can be regarded as a beneficial tool for discovery of new therapeutics for
diabetes and/or maturation of pancreatic progenitors (PP) towards β cells. Here, we devised …