The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …

Scientists have been fascinated by the human brain for centuries, yet knowledge of the
cellular and molecular events that build the human brain during embryogenesis and of how …

Brain development is an extraordinarily complex process achieved through the spatially and
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …

Highlights•Current understanding of human brain development comes mainly from animal
models.•Directly observing and manipulating the developing primate brain is …

Brain organoids are 3D self-assembled structures composed of hundreds of thousands to
millions of cells that resemble the cellular organization and transcriptional and epigenetic …

Brain organoids recapitulate in vitro the specific stages of in vivo human brain development,
thus offering an innovative tool by which to model human neurodevelopmental disease. We …

Brain organoids are self-assembled three-dimensional aggregates generated from
pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic …

The human brain is often described as the most complex organ in our body. Because of the
limited accessibility of living brain tissue, human-specific features of neurodevelopment and …

Understanding etiology of human neurological and psychiatric diseases is challenging.
Genomic changes, protracted development, and histological features unique to human brain …

The biology of the human brain, and in particular the dynamic interactions between the
numerous cell types and regions of the central nervous system, has been difficult to study …