C-type lectin receptors (CLRs) are diverse, trans-membrane proteins that function as pattern
recognition receptors (PRRs) which are necessary for orchestrating immune responses …

Dectin-2 is a C-type lectin receptor that recognizes high mannose polysaccharides.
Cryptococcus neoformans, a yeast-form fungal pathogen, is rich in polysaccharides in its cell …

Dectin-1, the innate immune receptor that recognizes β-glucan, plays an important role in
immunity against fungal pathogens. Paracoccidioides brasiliensis, the etiological agent of …

The cell walls and capsules of Cryptococcus neoformans, a yeast-type fungal pathogen, are
rich in polysaccharides. Dectin-2 is a C-type lectin receptor (CLR) that recognizes high …

Cryptococcus neoformans and Cryptococcus gattii cause life-threatening
meningoencephalitis or lung diseases in immunocompetent individuals or …

Phagocytosis by innate immune cells is an important process for protection against multiple
pathologies and is particularly important for resistance to infection. However, phagocytosis …

We assessed the role of Dectin-1 in the immune response to the pathogenic fungus
Coccidioides, both in vitro and in vivo, using mice with a targeted mutation in Clec7a …

Abstract Dectin-1 and Dectin-2 are type II transmembrane proteins of the C-type lectin family
with single carbohydrate recognition domains (CRDs) in their extracellular region. They are …

Interactions between commensal fungi and gut immune system are critical for establishing
colonic homeostasis. Here we found that mice deficient in Dectin-3 (Clec4d-/-), a C-type …

Background Streptococcus pneumoniae, a major causative bacterial pathogen of community-
acquired pneumonia, possesses a thick polysaccharide capsule. Host defense against this …