Context-specific Polycomb mechanisms in development

JJ Kim, RE Kingston - Nature Reviews Genetics, 2022 - nature.com
Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

Regulation of gene transcription by Polycomb proteins

S Aranda, G Mas, L Di Croce - Science advances, 2015 - science.org
The Polycomb group (PcG) of proteins defines a subset of factors that physically associate
and function to maintain the positional identity of cells from the embryo to adult stages. PcG …

A new world of Polycombs: unexpected partnerships and emerging functions

YB Schwartz, V Pirrotta - Nature Reviews Genetics, 2013 - nature.com
Polycomb group (PcG) proteins are epigenetic repressors that are essential for the
transcriptional control of cell differentiation and development. PcG-mediated repression is …

Polycomb complexes and epigenetic states

YB Schwartz, V Pirrotta - Current opinion in cell biology, 2008 - Elsevier
Important advances in the study of Polycomb Group (PcG) complexes in the past two years
have focused on the role of this repressive system in programing the genome. Genome-wide …

Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice

B Schuettengruber, G Cavalli - Development, 2009 - journals.biologists.com
Polycomb group (PcG) protein complexes dynamically define cellular identity through the
regulation of key developmental genes. Important advances in the PcG field have come from …

Regulation of genome architecture and function by polycomb proteins

M Entrevan, B Schuettengruber, G Cavalli - Trends in cell biology, 2016 - cell.com
Polycomb group (PcG) proteins dynamically define cellular identities through the epigenetic
repression of key developmental regulatory genes. PcG proteins are recruited to specific …

Concise review: roles of polycomb group proteins in development and disease: a stem cell perspective

VK Rajasekhar, M Begemann - Stem cells, 2007 - academic.oup.com
The acquisition and maintenance of cell fate are essential for metazoan growth and
development. A strict coordination between genetic and epigenetic programs regulates cell …

Interpretation of developmental signaling at chromatin: the Polycomb perspective

R Sawarkar, R Paro - Developmental cell, 2010 - cell.com
The Polycomb group (PcG) system represses the transcription of important developmental
regulators and perpetuates this repression across multiple cell divisions. Inputs from outside …

Polycomb group complexes–many combinations, many functions

TK Kerppola - Trends in cell biology, 2009 - cell.com
Polycomb Group (PcG) proteins are transcription regulatory proteins that control the
expression of a variety of genes from early embryogenesis through birth to adulthood. PcG …

Mechanisms of Polycomb group protein function in cancer

V Parreno, AM Martinez, G Cavalli - Cell research, 2022 - nature.com
Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …