The lack of reliable measures of alcohol intake is a major obstacle to the diagnosis and
treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation …

Genetic, epigenetic, and environmental factors influence the development of alcohol
dependence (AD). Recent studies have shown that DNA methylation markers in peripheral …

DNA methylation may be one of the mechanisms by which alcohol consumption is
associated with the risk of disease. We conducted a large‐scale, cross‐sectional, genome …

Background Epigenetic regulation through DNA methylation may influence vulnerability to
numerous disorders, including alcohol dependence (AD). Methods Peripheral blood DNA …

Chronic alcohol intake is associated with a wide variety of adverse health outcomes
including depression, diabetes, and heart disease. Unfortunately, the molecular …

Alcohol use disorder (AUD) is a major contributor to morbidity and mortality worldwide.
Although there is a heritable component, the etiology of AUD is complex and can involve …

Alcoholism has a profound impact on millions of people throughout the world. However, the
ability to determine if a patient needs treatment is hindered by reliance on self-reporting and …

DNA methylome alterations in the prefrontal cortex (PFC) may contribute to risk for alcohol
use disorders (AUDs). We examined postmortem PFC DNA methylomes of 16 male and …

Substance abuse has an enormous impact on economic and quality of life measures
throughout the world. In more developed countries, overutilization of the most common forms …

Environmental factors, including substance abuse and stress, cause long-lasting changes in
the regulation of gene expression in the brain via epigenetic mechanisms, such as DNA …