Purpose The aim of this study was to establish a comprehensive prenatal diagnosis service
and to control the birth of thalassemia children in Guangxi Zhuang Automonous Region …

OBJECTIVE: To control the birth of thalassemic children in Southern China. STUDY
DESIGN: DNA-based diagnosis was offered on fetal tissues in pregnancies when β-globin …

In this paper β-globin gene mutations were detected in 452 β-thalassemia carriers from 13
462 unselected individuals (6731 pregnant women and their husbands) who were screened …

Background To date, there has been no systematic study of DNA‐based prenatal diagnosis
of thalassemia in pregnant Hakka women in southern China. Methods A total of 279 …

Thalassaemia is highly prevalent in southeastern China. This 10‐year follow‐up study
aimed to characterize the genotype and karyotype of thalassaemia in fetal samples derived …

β-Thalassemia (thal) is the most common genetic disease and is widely distributed in
southern China. Prenatal diagnosis is needed to prevent the birth of thalassemic offspring in …

β-Thalassemia is a common disease in Southern China and 10 different mutations or
frameshifts are responsible for most types of β-thalassemia in this area. We studied 126 …

This study is a retrospective analysis of the prenatal genetic diagnosis results of fetuses with
high risk of major thalassemia to provide information for clinical genetic counseling and to …

Objectives Although the population prevalence and mutation spectrum of β-thalassemia in
most areas of south China have been characterized, the mutations have not been elucidated …

Thalassemia is one of the most common monogenic diseases in southern China1. Carriers
of thalassemia are usually asymptomatic. However, they have a 25% chance of having …