H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos
H Mei, C Kozuka, R Hayashi, M Kumon, H Koseki… - Nature …, 2021 - nature.com
Parental epigenomes are established during gametogenesis. While they are largely reset
after fertilization, broad domains of Polycomb repressive complex 2 (PRC2)-mediated …
after fertilization, broad domains of Polycomb repressive complex 2 (PRC2)-mediated …
Distinct dynamics and functions of H2AK119ub1 and H3K27me3 in mouse preimplantation embryos
Polycomb repressive complexes 1 and 2 (PRC1/2) maintain transcriptional silencing of
developmental genes largely by catalyzing the formation of mono-ubiquitinated histone H2A …
developmental genes largely by catalyzing the formation of mono-ubiquitinated histone H2A …
[HTML][HTML] Resetting epigenetic memory by reprogramming of histone modifications in mammals
Polycomb group proteins and the related histone modification H3K27me3 can maintain the
silencing of key developmental regulators and provide cellular memory. However, how such …
silencing of key developmental regulators and provide cellular memory. However, how such …
[HTML][HTML] Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity
H3K27me3 is deposited at promoters by the preferential association of Polycomb repressive
complex 2 (PRC2) with CpG-rich DNA elements regulating development by repressing gene …
complex 2 (PRC2) with CpG-rich DNA elements regulating development by repressing gene …
Germ line–inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition
Gametes carry parental genetic material to the next generation. Stress-induced epigenetic
changes in the germ line can be inherited and can have a profound impact on offspring …
changes in the germ line can be inherited and can have a profound impact on offspring …
[HTML][HTML] PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome
TG Meng, Q Zhou, XS Ma, XY Liu, QR Meng… - Nature …, 2020 - nature.com
The formation of zygote is the beginning of mammalian life, and dynamic epigenetic
modifications are essential for mammalian normal development. H3K27 di-methylation …
modifications are essential for mammalian normal development. H3K27 di-methylation …
Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation
Polycomb-group proteins play critical roles in gene silencing through the deposition of
histone H3 lysine 27 trimethylation (H3K27me3) and chromatin compaction. This process is …
histone H3 lysine 27 trimethylation (H3K27me3) and chromatin compaction. This process is …
[HTML][HTML] The H3K36me2 methyltransferase Nsd1 demarcates PRC2-mediated H3K27me2 and H3K27me3 domains in embryonic stem cells
The Polycomb repressor complex 2 (PRC2) is composed of the core subunits Ezh1/2,
Suz12, and Eed, and it mediates all di-and tri-methylation of histone H3 at lysine 27 in …
Suz12, and Eed, and it mediates all di-and tri-methylation of histone H3 at lysine 27 in …
Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2
JW Højfeldt, A Laugesen, BM Willumsen… - Nature structural & …, 2018 - nature.com
Abstract Polycomb repressive complex 2 (PRC2) catalyzes methylation on lysine 27 of
histone H3 (H3K27) and is required for maintaining transcriptional patterns and cellular …
histone H3 (H3K27) and is required for maintaining transcriptional patterns and cellular …
Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
GL Brien, G Gambero, DJ O'connell, E Jerman… - Nature structural & …, 2012 - nature.com
Polycomb group proteins are repressive chromatin modifiers with essential roles in
metazoan development, cellular differentiation and cell fate maintenance. How Polycomb …
metazoan development, cellular differentiation and cell fate maintenance. How Polycomb …