Polycystic kidney disease (PKD) is an inherited disorder that is characterized by the
accumulation of cysts in the renal parenchyma and progressive decline in renal function …

Abnormalities in the primary cilium perturb signaling pathways that regulate renal epithelial
cell growth and differentiation and lead to the formation of kidney cysts. Acute kidney injury …

Significant progress in understanding the molecular mechanisms of polycystic kidney
disease (PKD) has been made in recent years. Translating this understanding into effective …

Primary cilia dysfunction alters renal tubular cell proliferation and differentiation and
associates with accelerated cyst formation in polycystic kidney disease. However, the …

Polycystic kidney disease (PKD), comprising autosomal dominant polycystic kidney disease
(ADPKD) and autosomal recessive polycystic kidney d isease (ARPKD), is characterized by …

The congenital polycystic kidney (cpk) mutation is the most extensively characterized mouse
model of polycystic kidney disease (PKD). The renal cystic disease is fully expressed in …

Delayed cystogenesis and increased ciliogenesis associated with the re-expression of
polaris inTg737 mutant mice. Background Renal cysts and shortened cilia on renal tubular …

Cysts in the kidney are among the most common inherited human pathologies, and recent
research has uncovered that a defect in cilia-mediated signaling activity is a key factor that …

Zebrafish are an attractive model for studying the earliest cellular defects occurring during
renal cyst formation because its kidney (the pronephros) is simple and genes that cause …

Defects in the PKD1 and PKD2 genes cause autosomal dominant polycystic kidney disease
(PKD) in~ 1 in 1000 adults worldwide. These genes encode polycystin-1 and polycystin-2 …