The incidence rate and histological characteristics of intimal hyperplasia in elastase‐induced experimental abdominal aortic aneurysms in mice

M Li, P Wei, K Li, H Liu, N Alam, H Hou… - Animal Models and …, 2023 - Wiley Online Library
Intimal hyperplasia (IH) is a negative vascular remodeling after arterial injury. IH
occasionally occurs in elastase‐induced abdominal aortic aneurysm (AAA) mouse models …

Extra-and intraluminal elastase induce morphologically distinct abdominal aortic aneurysms in mice and thus represent specific subtypes of human disease

A Busch, A Holm, N Wagner, S Ergün… - Journal of vascular …, 2016 - karger.com
Topical application of elastase to induce arterial aneurysm formation is an emerging murine
model of vascular disease. In the context of aortic abdominal aneurysm (AAA), angiotensin II …

Experimental aortic aneurysm severity and growth depend on topical elastase concentration and lysyl oxidase inhibition

AG Berman, DJ Romary, KE Kerr, NE Gorazd… - Scientific reports, 2022 - nature.com
Abdominal aortic aneurysm (AAA) formation and expansion is highly complex and
multifactorial, and the improvement of animal models is an important step to enhance our …

Differential gender-and species-specific formation of aneurysms using a novel method of inducing abdominal aortic aneurysms

A Laser, G Lu, A Ghosh, K Roelofs, B McEvoy… - journal of surgical …, 2012 - Elsevier
BACKGROUND: The objective of this study was to test a novel model of inducing abdominal
aortic aneurysms (AAAs) in different mouse strains and genders. MATERIALS AND …

Temporal and Quantitative Analysis of Aortic Immunopathologies in Elastase‐Induced Mouse Abdominal Aortic Aneurysms

K Tian, C Xia, H Liu, B Xu, P Wei, W Fu… - Journal of …, 2021 - Wiley Online Library
Objective. Elastase‐induced abdominal aortic aneurysm (AAA) model is widely used for
aneurysmal pathogenesis and translational research. However, temporal alternations in …

[HTML][HTML] Hyperlipidemia does not affect development of elastase-induced abdominal aortic aneurysm in mice

J Mulorz, JM Spin, HC Beck, MLT Thi… - Atherosclerosis, 2020 - Elsevier
Background and aims Hyperlipidemia is a suggested risk factor for abdominal aortic
aneurysm (AAA). However, whether hyperlipidemia is causally involved in AAA progression …

[HTML][HTML] In vivo assessment of murine elastase-induced abdominal aortic aneurysm with high resolution magnetic resonance imaging

MA Bartoli, F Kober, P Cozzone, RW Thompson… - European Journal of …, 2012 - Elsevier
OBJECTIVES: There are, to date, no published non-invasive or longitudinal studies
performed in mice to measure aortic diameter and wall thickness in an elastase-induced …

Indomethacin prevents elastase-induced abdominal aortic aneurysms in the rat

DR Holmes, D Petrinec, W Wester… - Journal of Surgical …, 1996 - Elsevier
Perfusion of the rat abdominal aorta with elastase induces abdominal aortic aneurysms
(AAA), in which the development of aortic dilatation correlates with the influx of inflammatory …

[HTML][HTML] Temporal changes in mouse aortic wall gene expression during the development of elastase-induced abdominal aortic aneurysms

SJ Van Vickle-Chavez, WS Tung, TS Absi… - Journal of vascular …, 2006 - Elsevier
OBJECTIVE: To characterize temporal changes in mouse aortic wall gene expression
associated with the development of experimental abdominal aortic aneurysms. METHODS …

Degeneration and Regeneration of Smooth Muscle Cells in Two Different Abdominal Aortic Aneurysm Models in Rabbits

Y Bi, J Guo, M Yi, Y Gao, J Ren, X Han - Annals of Vascular Surgery, 2022 - Elsevier
Background We aimed to investigate the formation and self-healing process of rabbit
abdominal aortic aneurysm (AAA) by focus on the degeneration and regeneration of smooth …