DNA methylation is an epigenetic mark that is erased in the early embryo and then re-
established at the time of implantation. In this Review, dynamics of DNA methylation during …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

Ever since the discovery of DNA methylation at cytosine residues, the role of this so called
fifth base has been extensively studied and debated. Until recently, the majority of DNA …

One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …

The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …

DNA methylation is known to be abnormal in all forms of cancer, but it is not really
understood how this occurs and what is its role in tumorigenesis. In this review, we take a …

DNA methylation acts in concert with other epigenetic mechanisms to regulate normal gene
expression and facilitate chromatin organization within cells. Aberrant DNA methylation …

DNA methylation is a stable epigenetic mark that can be inherited through multiple cell
divisions. During development and cell differentiation, DNA methylation is dynamic, but …

DNA methylation is a crucial epigenetic modification of the genome that is involved in
regulating many cellular processes. These include embryonic development, transcription …