In autosomal dominant polycystic kidney disease (ADPKD), the inexorable growth of
numerous fluid-filled cysts leads to massively enlarged kidneys, renal interstitial damage …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by innumerous
fluid-filled cysts and progressive deterioration of renal function. Previously, we showed that …

Polycystic kidney disease (PKD) is a commonly inherited disorder characterized by cyst
formation and fibrosis (Wilson, N Engl J Med 350: 151–164, 2004) and is caused by …

Polycystic kidney disease: Primary extracellular matrix abnormality or defective cellular
differentiation? Polycystic kidney disease (PKD) is inherited as a dominant or recessive trait …

Abstract Dysregulation of polycystin-1 (PC1) leads to autosomal dominant polycystic kidney
disease (ADPKD), a disorder characterized by the formation of multiple bilateral renal cysts …

Extracellular matrix alterations have been suggested to be part of the early events occurring
in Autosomal Dominant Polycystic Kidney Disease (ADPKD), a disease characterized by …

Renal cyst enlargement in autosomal dominant polycystic kidney disease (ADPKD) is
characterized by increased epithelial cell proliferation and fluid accumulation. Using …

Polycystic kidney disease (PKD), in which epithelial cysts arise from or instead of normal
renal tubules, is one of the most common genetic diseases. It has both autosomal dominant …

In polycystic kidney disease (PKD), persistent activation of cell proliferation and matrix
production contributes to cyst growth and fibrosis, leading to progressive deterioration of …

Abstract Background Polycystic Kidney Disease (PKD) kidneys exhibit increased
extracellular matrix (ECM) collagen expression and metalloproteinases (MMPs) activity. We …