The extracellular matrix (ECM) is an interconnected macromolecular scaffold occupying the
space between cells. Amongst other functions, the ECM provides structural support to …

Skeletal muscle requires a highly orchestrated coordination between multiple cell types and
their microenvironment to exert its function and to maintain its homeostasis and regenerative …

Skeletal muscle represents the largest body-composition component in humans. In addition
to its primary function in the maintenance of upright posture and the production of …

As the primary producer of extracellular matrix (ECM) proteins in skeletal muscle, fibroblasts
play an important role providing structural support to muscle. Skeletal muscle ECM is vital for …

The regenerative ability of skeletal muscle (SM) in response to damage, injury, or disease is
a highly intricate process that involves the coordinated activities of multiple cell types and …

Age‐related declines in skeletal muscle regeneration have been attributed to muscle stem
cell (MuSC) dysfunction. Aged MuSCs display a fibrogenic conversion, leading to fibrosis …

Skeletal muscle regeneration occurs by the activation, proliferation and fusion of muscle
precursor cells (myoblasts) that usually lie in a satellite cell position on the surface of the …

Skeletal muscle tissue makes up approximately 40% of the total body mass in adult
mammals. Contractile muscle fibers building skeletal muscle tissue are coated by an …

Skeletal muscle is endowed with a remarkable capacity for regeneration, primarily due to the
reserve pool of muscle resident satellite cells. The satellite cell is the physiologically …

Mammalian skeletal muscle is notable for both its highly ordered biophysical structure and
its regenerative capacity following trauma. Critical to both of these features is the specialized …