The ubiquitin-proteasome system is a major regulatory pathway of protein degradation and
plays an important role in cellular division. Fbxw7 (or hCdc4), a member of the F-box family …

Fbxw7 (also known as Sel‐10, hCdc4 or hAgo) is the F‐box protein component of a Skp1–
Cul1–F‐box protein (SCF) ubiquitin ligase. Fbxw7 contributes to the ubiquitin‐mediated …

Fbxw7/hCdc4 is a member of the F-box family of proteins, which function as interchangeable
substrate recognition components of the SCF ubiquitin ligases. SCFFbxw7/hCdc4 targets …

The ubiquitin-proteasome system (UPS) is involved in multiple aspects of cellular processes,
such as cell cycle progression, cellular differentiation, and survival (Davis RJ et al., Cancer …

FBXW7 (also known as Fbw7, Sel10, hCDC4, or hAgo) is a tumor suppressor and the most
frequently mutated member of the F-box protein family in human cancers. FBXW7 functions …

Abstract FBXW7 (F-Box and WD Repeat Domain Containing 7)(also referred to as FBW7 or
hCDC4) is a component of the Skp1-Cdc53/Cullin-F-box-protein complex (SCF/β-TrCP). As …

SCF ubiquitin ligases regulate the degradation of many proteins involved in thecontrol of cell
division and growth. F-box proteins are the SCF components that bind tosubstrates, and this …

Rapidly accumulating data indicate that F-box/WD repeat-containing protein 7 (Fbxw7) is
one of the most frequently mutated genes in human cancers and regulates a network of …

Fbw7 is a member of F-box family proteins, which constitute one subunit of Skp1, Cul1, and
F-box protein (SCF) ubiquitin ligase complex. SCF Fbw7 targets a set of well-known …

The human tumor suppressor Fbw7/hCdc4 functions as a phosphoepitope-specific substrate
recognition component of SCF ubiquitin ligases [1] that catalyzes the ubiquitination of cyclin …