Mitochondrial DNA (mtDNA) mutations are a relatively common cause of progressive
disorders that can be severe or even life-threatening. There is currently no cure for these …

Mitochondrial disorders represent the most common group of inborn errors of metabolism.
Clinical manifestations can be extremely variable, ranging from single affected tissues to …

Mitochondrial medicine is one of the few areas of genetic disease where germ-line transfer
is being actively pursued as a treatment option. All of the germ-line transfer methods …

BACKGROUND The use of nuclear transfer (NT) has been proposed as a novel
reproductive treatment to overcome the transmission of maternally-inherited mitochondrial …

Mitochondria, the ubiquitous power packs in nearly every eukaryotic cell, contain their own
DNA, known as mt DNA, which is inherited exclusively from the mother. The number of …

BACKGROUND: Mitochondrial diseases are caused by the mutations in both nuclear and
mitochondrial DNA (mtDNA) and the treatment options for patients who have mitochondrial …

While the fertilized egg inherits its nuclear DNA from both parents, the mitochondrial DNA is
strictly maternally inherited. Cells contain multiple copies of mtDNA, each of which encodes …

Mitochondrial DNA is maternally inherited, and pathogenic mutations cause a range of life-
limiting conditions. Recent studies indicate that transmission of pathogenic mutations may …

Genetic defects of the mitochondrial genome can be especially devastating to patients;
moreover, attention on human mitochondrial disorders has grown remarkably in recent …

Mitochondrialreplacementtherapy, an experimental approach that takes aim at maternally
inherited mitochondrial diseases, is on the verge of being implemented in the United …