Mutations in the PKD1 gene are responsible for 85% of cases of autosomal dominant
polycystic kidney disease (ADPKD). This gene encodes a large membrane associated …

Most cases of autosomal dominant polycystic kidney disease (ADPKD) are the result of
mutations in the PKD1 gene. The PKD1 gene codes for a large cell‐surface glycoprotein …

The most common form of autosomal dominant polycystic kidney disease (PKD) results from
mutation of the PKD1 gene on chromosome 16p13. 3. The gene encodes a 14-kb …

Mutations in the PKD1 gene are responsible for> 85% of autosomal dominant polycystic
kidney disease (ADPKD). The protein product of PKD1, polycystin-1, is a large, modular …

The 14 kb mRNA of the polycystic kidney disease gene PKD1 encodes a novel large (~ 460
kDa) protein, polycystin-1, of unknown function that is responsible for autosomal dominant …

PKD2, the second gene for the autosomal dominant polycystic kidney disease (ADPKD),
encodes a protein, polycystin-2, with predicted structural similarity to cation channel …

PKD1, the gene that is mutated in approximately 85% of autosomal dominant polycystic
kidney disease (ADPKD) cases in humans, has recently been identified (Eur. PKD …

Using a positional cloning approach the major autosomal dominant polycystic kidney
disease (ADPKD) gene (PKD1) has been identified on chromosome 16: a disease …

Mutations in the PKD1 gene are the most common cause of autosomal dominant polycystic
kidney disease (ADPKD). Other PKD1-like loci on chromosome 16 are approximately 97 …

Mutations in the PKD1 gene are the most common cause of autosomal dominant polycystic
kidney disease (ADPKD). Other PKD1-like loci on chromosome 16 are approximately 97 …