cRGD-decorated biodegradable polytyrosine nanoparticles for robust encapsulation and targeted delivery of doxorubicin to colorectal cancer in vivo

X Gu, Y Wei, Q Fan, H Sun, R Cheng, Z Zhong… - Journal of controlled …, 2019 - Elsevier
The clinical success of nanomedicines demands on the development of simple
biodegradable nanocarriers that can efficiently and stably encapsulate chemotherapeutics …

Polytyrosine nanoparticles enable ultra-high loading of doxorubicin and rapid enzyme-responsive drug release

X Gu, M Qiu, H Sun, J Zhang, L Cheng, C Deng… - Biomaterials …, 2018 - pubs.rsc.org
Despite the great significance of clinically viable nanovehicles, very few of them exhibit
stability and high anticancer drug loading with fast intracellular drug release. Herein, we …

Galactoxyloglucan-modified nanocarriers of doxorubicin for improved tumor-targeted drug delivery with minimal toxicity

MM Joseph, SR Aravind, SK George… - Journal of …, 2014 - ingentaconnect.com
Doxorubicin (Dox) is commonly used to treat human malignancies, and the efficacy of Dox
can be maximized by limiting toxicity when combined with nanoparticles. PST-Dox …

Doxorubicin-loaded polysaccharide nanoparticles suppress the growth of murine colorectal carcinoma and inhibit the metastasis of murine mammary carcinoma in …

M Li, Z Tang, D Zhang, H Sun, H Liu, Y Zhang, Y Zhang… - Biomaterials, 2015 - Elsevier
As a synergistic drug combination, doxorubicin-loaded cisplatin crosslinked polysaccharide-
based nanoparticles (Dex-SA-DOX-CDDP) have demonstrated enhanced antitumor efficacy …

Construction of small-sized, robust, and reduction-responsive polypeptide micelles for high loading and targeted delivery of chemotherapeutics

S Xue, X Gu, J Zhang, H Sun, C Deng… - …, 2018 - ACS Publications
Polypeptide micelles, though having been proved to be an appealing nanoplatform for
cancer chemotherapy, are met with issues like inefficient drug encapsulation, gradual drug …

Functional cRGD-conjugated polymer prodrug for targeted drug delivery to liver cancer cells

R Zhou, M Zhang, J He, J Liu, X Sun, P Ni - ACS omega, 2022 - ACS Publications
To overcome the limitation of conventional nanodrugs in tumor targeting efficiency, coupling
targeting ligands to polymeric nanoparticles can enhance the specific binding of nanodrugs …

Screening of pH-responsive long-circulating polysaccharide–drug conjugate nanocarriers for antitumor applications

X Zhang, D Li, J Huang, K Ou, B Yan, F Shi… - Journal of materials …, 2019 - pubs.rsc.org
For the treatment of malignant tumors, drug nanocarriers with long blood circulation time and
ability to target the tumor microenvironment are promising therapeutic abilities. In this work …

Enhancing Doxorubicin Delivery toward Tumor by Hydroxyethyl Starch-g-Polylactide Partner Nanocarriers

C Yu, Q Zhou, F Xiao, Y Li, H Hu, Y Wan… - … applied materials & …, 2017 - ACS Publications
Doxorubicin (DOX), a kind of wide-spectrum chemotherapeutic drug, can cause severe side
effects in clinical use. To enhance its antitumor efficacy while reducing the side effects, two …

Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles

Q Xu, Y Liu, S Su, W Li, C Chen, Y Wu - Biomaterials, 2012 - Elsevier
Targeted delivery strategies are becoming increasingly important. Herein, a novel
hyperbranched amphiphilic poly [(amine-ester)-co-(d, l-lactide)]/1, 2-dipalmitoyl-sn-glycero-3 …

Dual pH/ROS‐responsive nanoplatform with deep tumor penetration and self‐amplified drug release for enhancing tumor chemotherapeutic efficacy

Y Li, M Chen, B Yao, X Lu, B Song, SN Vasilatos… - Small, 2020 - Wiley Online Library
Poor deep tumor penetration and incomplete intracellular drug release remain challenges
for antitumor nanomedicine application in clinical settings. Herein, a nanomedicine (RLPA …