cRGD-decorated biodegradable polytyrosine nanoparticles for robust encapsulation and targeted delivery of doxorubicin to colorectal cancer in vivo
The clinical success of nanomedicines demands on the development of simple
biodegradable nanocarriers that can efficiently and stably encapsulate chemotherapeutics …
biodegradable nanocarriers that can efficiently and stably encapsulate chemotherapeutics …
Polytyrosine nanoparticles enable ultra-high loading of doxorubicin and rapid enzyme-responsive drug release
Despite the great significance of clinically viable nanovehicles, very few of them exhibit
stability and high anticancer drug loading with fast intracellular drug release. Herein, we …
stability and high anticancer drug loading with fast intracellular drug release. Herein, we …
Galactoxyloglucan-modified nanocarriers of doxorubicin for improved tumor-targeted drug delivery with minimal toxicity
Doxorubicin (Dox) is commonly used to treat human malignancies, and the efficacy of Dox
can be maximized by limiting toxicity when combined with nanoparticles. PST-Dox …
can be maximized by limiting toxicity when combined with nanoparticles. PST-Dox …
Doxorubicin-loaded polysaccharide nanoparticles suppress the growth of murine colorectal carcinoma and inhibit the metastasis of murine mammary carcinoma in …
As a synergistic drug combination, doxorubicin-loaded cisplatin crosslinked polysaccharide-
based nanoparticles (Dex-SA-DOX-CDDP) have demonstrated enhanced antitumor efficacy …
based nanoparticles (Dex-SA-DOX-CDDP) have demonstrated enhanced antitumor efficacy …
Construction of small-sized, robust, and reduction-responsive polypeptide micelles for high loading and targeted delivery of chemotherapeutics
Polypeptide micelles, though having been proved to be an appealing nanoplatform for
cancer chemotherapy, are met with issues like inefficient drug encapsulation, gradual drug …
cancer chemotherapy, are met with issues like inefficient drug encapsulation, gradual drug …
Functional cRGD-conjugated polymer prodrug for targeted drug delivery to liver cancer cells
R Zhou, M Zhang, J He, J Liu, X Sun, P Ni - ACS omega, 2022 - ACS Publications
To overcome the limitation of conventional nanodrugs in tumor targeting efficiency, coupling
targeting ligands to polymeric nanoparticles can enhance the specific binding of nanodrugs …
targeting ligands to polymeric nanoparticles can enhance the specific binding of nanodrugs …
Screening of pH-responsive long-circulating polysaccharide–drug conjugate nanocarriers for antitumor applications
For the treatment of malignant tumors, drug nanocarriers with long blood circulation time and
ability to target the tumor microenvironment are promising therapeutic abilities. In this work …
ability to target the tumor microenvironment are promising therapeutic abilities. In this work …
Enhancing Doxorubicin Delivery toward Tumor by Hydroxyethyl Starch-g-Polylactide Partner Nanocarriers
C Yu, Q Zhou, F Xiao, Y Li, H Hu, Y Wan… - … applied materials & …, 2017 - ACS Publications
Doxorubicin (DOX), a kind of wide-spectrum chemotherapeutic drug, can cause severe side
effects in clinical use. To enhance its antitumor efficacy while reducing the side effects, two …
effects in clinical use. To enhance its antitumor efficacy while reducing the side effects, two …
Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles
Q Xu, Y Liu, S Su, W Li, C Chen, Y Wu - Biomaterials, 2012 - Elsevier
Targeted delivery strategies are becoming increasingly important. Herein, a novel
hyperbranched amphiphilic poly [(amine-ester)-co-(d, l-lactide)]/1, 2-dipalmitoyl-sn-glycero-3 …
hyperbranched amphiphilic poly [(amine-ester)-co-(d, l-lactide)]/1, 2-dipalmitoyl-sn-glycero-3 …
Dual pH/ROS‐responsive nanoplatform with deep tumor penetration and self‐amplified drug release for enhancing tumor chemotherapeutic efficacy
Y Li, M Chen, B Yao, X Lu, B Song, SN Vasilatos… - Small, 2020 - Wiley Online Library
Poor deep tumor penetration and incomplete intracellular drug release remain challenges
for antitumor nanomedicine application in clinical settings. Herein, a nanomedicine (RLPA …
for antitumor nanomedicine application in clinical settings. Herein, a nanomedicine (RLPA …