Brain development is guided by the interactions between the genetic blueprint and the
environment. Epigenetic mechanisms, especially DNA methylation, can mediate these …

Psychiatric disorders are common, complex, and heritable conditions estimated to be the
leading cause of disability worldwide. The last decade of research in genomics of psychiatry …

Epigenetic mechanisms regulate gene expression, influencing protein levels and ultimately
shaping phenotypes during life. However, both stochastic epigenetic variations and …

Background Major depressive disorder (MDD) is a disabling mood disorder, and despite a
known heritable component, a large meta-analysis of genome-wide association studies …

Histone modifications and DNA methylation represent central dynamic and reversible
processes that regulate gene expression and contribute to cellular phenotypes. These …

Precise genetic and epigenetic spatiotemporal regulation of gene expression is critical for
proper brain development, function and circuitry formation in the mammalian central nervous …

The general psychopathology factor (GPF) has been proposed as a way to capture variance
shared between psychiatric symptoms. Despite a growing body of evidence showing both …

Schizophrenia is a complex disorder of the brain, where genetic variants explain only a
portion of risk. Neuroepigenetic mechanisms may explain the remaining share of risk, as …

Major depressive disorder (MDD) is a complex, heritable psychiatric disorder. Advanced
statistical genetics for genome-wide association studies (GWASs) have suggested that the …

DNA methylation (DNAm) is important in brain development and is potentially important in
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …