Hypercapnia challenge (eg inhalation of CO2) has been used in calibrated fMRI as well as
in the mapping of vascular reactivity in cerebrovascular diseases. An important assumption …

The effect of carbon dioxide (CO2) on cerebral metabolism is of tremendous interest to
functional imaging. In particular, mild-to-moderate hypercapnia is routinely used in …

A better understanding of carbon dioxide (CO2) effect on brain activity may have a profound
impact on clinical studies using CO2 manipulation to assess cerebrovascular reserve and …

Respiratory challenge MRI is the modification of arterial oxygen (PaO 2) and/or carbon
dioxide (PaCO 2) concentration to induce a change in cerebral function or metabolism which …

Cerebrovascular reactivity (CVR) is an indicator of cerebrovascular reserve and provides
important information about vascular health in a range of brain conditions and diseases …

Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI)
is most commonly used in a semi-quantitative manner to infer changes in brain activity …

Calibrated fMRI relies on an iso-CMRO2 challenge to obtain the calibration factor. O2
challenge has been proposed to be a potential method for the calibration experiment …

The calibration of functional magnetic resonance imaging (fMRI) for the estimation of
neuronal activation-induced changes in cerebral metabolic rate of oxygen (CMRO2) has …

The physiological effect of hyperoxia has been poorly characterize d, with studies reporting
conflicting results on the role of hyperoxia as a vasoconstrictor. It is not clear whether …

Blood oxygenation level-dependent (BOLD) or arterial spin labeling (ASL) MRI with
hypercapnic stimuli allow for measuring cerebrovascular reactivity (CVR). Hypercapnic …