Globally, diabetes is the leading cause of chronic kidney disease and end-stage renal
disease, which are major risk factors for cardiovascular disease and death. Despite this …

The kidneys are highly metabolic organs that produce vast quantities of adenosine
triphosphate via oxidative phosphorylation and, as such, contain many mitochondria …

Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD) in
the USA. The pathogenesis of DKD is multifactorial and involves activation of multiple …

Although diabetic kidney disease (DKD) is the most common cause of end-stage kidney
disease worldwide, the pathogenic mechanisms are poorly understood. There is increasing …

Despite major improvements in the treatment of patients with diabetes mellitus, many
patients still suffer from progressive diabetic kidney disease. More research is needed to …

Recent advances have led to a greater appreciation of how mitochondrial dysfunction
contributes to diverse acute and chronic pathologies. Indeed, mitochondria have received …

The kidney requires a large number of mitochondria to remove waste from the blood and
regulate fluid and electrolyte balance. Mitochondria provide the energy to drive these …

Diabetic nephropathy (DN) is a progressive microvascular complication arising from
diabetes. Within the kidney, the glomeruli, tubules, vessels and interstitium are disrupted …

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) in
the United States and many other countries. DKD occurs through a variety of pathogenic …

Oxidative phosphorylation (OXPHOS) drives ATP production by mitochondria, which are
dynamic organelles, constantly fusing and dividing to maintain kidney homoeostasis. In …