Polycystin-1 (PC1), a 4,303-amino acid integral membrane protein of unknown function,
interacts with polycystin-2 (PC2), a 968-amino acid α-type channel subunit. Mutations in …

Polycystin-2 (PC-2) is a non-selective cation channel that, when mutated, results in
autosomal dominant polycystic kidney disease. In an effort to understand the regulation of …

Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent genetic disorder
largely caused by mutations in the PKD1 and PKD2 genes that encode the transmembrane …

Mutations in genes encoding polycystin-1 (PC1) and polycystin-2 cause autosomal
dominant polycystic kidney disease. The polycystin protein family is composed of Ca2+ …

Autosomal dominant polycystic kidney disease (PKD) is caused by mutation of polycystin-1
or polycystin-2. Polycystin-2 is a Ca 2+-permeable cation channel. Polycystin-1 is an integral …

Polycystin (PC) 1 and PC2 are membrane proteins implicated in autosomal dominant
polycystic kidney disease. A physiologically relevant cleavage at PC1's G protein-coupled …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the growth of
renal cysts that ultimately destroy kidney function. Mutations in the PKD1 and PKD2 genes …

Mutations in either polycystin‐2 (PC2) or polycystin‐1 (PC1) proteins cause severe,
potentially lethal, kidney disorders and multiple extrarenal (including brain) disease …

Analysis of the C-terminal cytosolic domain of human and mouse polycystin-1 has identified
a number of conserved protein motifs, including a 20-amino-acid heterotrimeric G-protein …

Polycystin-1 (Pc1) cleavage at the G protein-coupled receptor (GPCR) proteolytic site (GPS)
is required for normal kidney morphology in humans and mice. We found a complex pattern …