Previously, we found decreased mitochondrial complex I subunits levels and increased
protein oxidation and nitration in postmortem prefrontal cortex (PFC) from patients with …

Background: Recent studies indicate the presence of mitochondrial dysfunction in brains of
subjects with bipolar disorder (BD). Because the mitochondrial electron transport chain is a …

Context Accumulating evidence suggests that mitochondrial dysfunction and oxidative stress
contribute to the pathogenesis of bipolar disorder and schizophrenia. It remains unclear …

Background: Increased oxidative stress is strongly implicated in bipolar disorder (BD), where
protein oxidation, lipid peroxidation and oxidative damage to DNA have been consistently …

In this work, we review the studies of oxidative stress markers, showing association with the
pathophysiology of bipolar disorder (BD). BD is a prevalent, chronic and highly disabling …

Objective: Many studies indicate a genetic predisposition to bipolar disorder (BD) and
suggest that a number of abnormal genes are involved in its development. In this study, we …

BACKGROUND: Several independent lines of evidence indicate mitochondrial dysfunction
in schizophrenia in the brain and periphery, including mitochondrial hypoplasia, dysfunction …

Evidence suggests that mitochondrial dysfunction is involved in the pathophysiology of
psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BD). However, the …

The present study aims to investigate the oxidative stress parameters in isolated
mitochondria, as well as looking at mitochondrial complex activity in patients with Bipolar …

Bipolar disorder (BD) is a mental disorder characterized by recurrent relapses of affective
episodes, cognitive impairment, illness progression, and reduced life expectancy. Increased …