Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …

It has become clear over the last few years that DNA methylation is essential for normal
embryonic development and that alterations in DNA methylation are very common in cancer …

Cancer-associated DNA hypomethylation is as prevalent as cancer-linked hypermethylation,
but these two types of epigenetic abnormalities usually seem to affect different DNA …

The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …

The main thrusts of the arguments that aberrant DNA methylation is involved in the
generation of tumor heterogeneity and progression can be summarized as follows. The …

Cytosine methylation is a heritable modification of DNA in mammalian cells, and has a
determinant impact on long-term gene repression and genome stability. Genomic …

Alterations of DNA methylation are one of the most consistent epigenetic changes in human
cancers. Human cancers generally show global DNA hypomethylation accompanied by …

Epigenetic alterations such as DNA methylation have been implicated in the development
and progression of various cancers. DNA methylation consists of the reversible addition of a …

Recently, the concept that epigenetic, as well as genetic, events might be central to the
evolution of human cancer is re-emerging. Cancers often exhibit an aberrant methylation of …

▪ Abstract The past few years have seen a wider acceptance of a role for DNA methylation in
cancer. This can be attributed to three developments. First, the documentation of the over …