Factor I is required for the development of membranoproliferative glomerulonephritis in factor H–deficient mice

KL Rose, D Paixao-Cavalcante, J Fish… - The Journal of …, 2008 - Am Soc Clin Investig
The inflammatory kidney disease membranoproliferative glomerulonephritis type II (MPGN2)
is associated with dysregulation of the alternative pathway of complement activation …

Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice

MC Pickering, J Warren, KL Rose… - Proceedings of the …, 2006 - National Acad Sciences
Membranoproliferative glomerulonephritis (MPGN) type II (dense deposit disease) is an
inflammatory renal disease characterized by electron-dense deposits and complement C3 …

In situ complement activation in porcine membranoproliferative glomerulonephritis type II

JH Jansen, K Høgåsen, M Harboe, T Hovig - Kidney international, 1998 - Elsevier
In situ complement activation in porcine membranoproliferative glomerulonephritis type II.
Pigs genetically deficient in complement factor H all develop lethal membranoproliferative …

Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H

MC Pickering, HT Cook, J Warren, AE Bygrave… - Nature …, 2002 - nature.com
The alternative pathway of complement is activated continuously in vivo through the C3'tick-
over'pathway 1. This pathway is triggered by the hydrolysis of C3, resulting in the formation …

Characterization of a factor H mutation that perturbs the alternative pathway of complement in a family with membranoproliferative GN

EKS Wong, HE Anderson, AP Herbert… - Journal of the …, 2014 - journals.lww.com
Complement C3 activation is a characteristic finding in membranoproliferative GN (MPGN).
This activation can be caused by immune complex deposition or an acquired or inherited …

Role of the complement membrane attack complex (C5b-9) in mediating experimental mesangioproliferative glomerulonephritis

J Brandt, J Pippin, M Schulze, GM Hänsch, CE Alpers… - Kidney international, 1996 - Elsevier
Role of the complement membrane attack complex (C5b-9) in mediating experimental
mesangioproliferative glomerulonephritis. Previous studies have demonstrated that most …

Contrasting roles of complement activation and its regulation in membranous nephropathy

PN Cunningham, RJ Quigg - Journal of the American Society of …, 2005 - journals.lww.com
The complement system is involved in defense against microorganisms, the processing of
immune complexes and apoptotic debris, and the development of an appropriate immune …

Classical complement pathway activation in membranoproliferative glomerulonephritis

YM Ooi, EH Vallota, CD West - Kidney International, 1976 - Elsevier
Classical complement pathway activation in membranoprolifera-tive glomerulonephritis.
Levels of components of the classical and alternative complement pathways and the activity …

Membranoproliferative glomerulonephritis with C3NeF and genetic complement dysregulation

V Leroy, V Fremeaux-Bacchi, M Peuchmaur… - Pediatric …, 2011 - Springer
The development of membranoproliferative glomerulonephritis (MPGN) is associated with
uncontrolled activation of the complement alternative pathway. This dysregulation is related …

Patterns of complement activation in idiopathic membranoproliferative glomerulonephritis, types I, II, and III

WS Varade, J Forristal, CD West - American Journal of Kidney Diseases, 1990 - Elsevier
Complement profiles on 22 hypocomplementemic patients with membranoproliferative
glomerulonephritis (MPGN) type I, on 11 with MPGN II, and on 16 with MPGN III, gave …