Protocol for the Metformin Aneurysm Trial (MAT): a placebo-controlled randomised trial testing whether metformin reduces the risk of serious complications of …
Background Multiple observational studies have associated metformin prescription with
reduced progression of abdominal aortic aneurysm (AAA). The Metformin Aneurysm Trial …
reduced progression of abdominal aortic aneurysm (AAA). The Metformin Aneurysm Trial …
[HTML][HTML] Editor's Choice–Association between metformin prescription and abdominal aortic aneurysm growth and clinical events: a systematic review and meta …
Objective A meta-analysis of the association between metformin prescription and abdominal
aortic aneurysm (AAA) growth and events (rupture or surgical repair) was performed …
aortic aneurysm (AAA) growth and events (rupture or surgical repair) was performed …
Association of metformin use with abdominal aortic aneurysm: A systematic review and meta-analysis
R Dewangga, K Winston, LG Ilhami… - Asian …, 2024 - journals.sagepub.com
Background Abdominal aortic aneurysm (AAA) is a cardiovascular disease characterized by
a high mortality rate when ruptured. Some studies suggest a potential inverse correlation …
a high mortality rate when ruptured. Some studies suggest a potential inverse correlation …
[HTML][HTML] Editor's choice–metformin prescription is associated with a reduction in the combined incidence of surgical repair and rupture related mortality in patients with …
J Golledge, DR Morris, J Pinchbeck… - European Journal of …, 2019 - Elsevier
Objectives Currently there is no drug therapy for abdominal aortic aneurysm (AAA) and most
previous investigations have focused on imaging rather than clinical outcomes. The aim of …
previous investigations have focused on imaging rather than clinical outcomes. The aim of …
[PDF][PDF] Background and proposed design for a metformin abdominal aortic aneurysm supression trial
R Dalman, Y Lu, K Mahaffey, A Chase… - Vascular & …, 2020 - verjournal.com
Abdominal aortic aneurysm (AAA) may lead to rupture and death if left untreated. While
endovascular or surgical repair is generally recommended for AAA greater than 5–5.5 cm …
endovascular or surgical repair is generally recommended for AAA greater than 5–5.5 cm …
The protective effect of metformin on abdominal aortic aneurysm: a systematic review and meta-analysis
Z Yuan, Z Heng, Y Lu, J Wei, Z Cai - Frontiers in Endocrinology, 2021 - frontiersin.org
Background Type 2 diabetes mellitus (T2DM) patients have a lower risk of abdominal aortic
aneurysm (AAA) and its comorbidities, which might be associated with the usage of …
aneurysm (AAA) and its comorbidities, which might be associated with the usage of …
Association of metformin and abdominal aortic aneurysm repair outcomes
A Turowicz, J Kobecki, A Laskowska… - Annals of Vascular …, 2021 - Elsevier
Background Metformin is a commonly used drug in diabetes mellitus treatment. Recently it
has been suggested that the use of metformin on diabetes mellitus patients may lower the …
has been suggested that the use of metformin on diabetes mellitus patients may lower the …
Association between metformin prescription and growth rates of abdominal aortic aneurysms
Background It has been suggested that diabetes medications, such as metformin, may have
effects that inhibit abdominal aortic aneurysm (AAA) growth. The aim of this study was to …
effects that inhibit abdominal aortic aneurysm (AAA) growth. The aim of this study was to …
[HTML][HTML] Metformin treatment does not affect the risk of ruptured abdominal aortic aneurysms
KL Kristensen, A Pottegård, J Hallas… - Journal of vascular …, 2017 - Elsevier
Objective Diabetes counteracts formation and rupture of abdominal aortic aneurysms,
possibly through arterial matrix accumulation. Use of metformin, on the other hand, reduces …
possibly through arterial matrix accumulation. Use of metformin, on the other hand, reduces …
The metformin for abdominal aortic aneurysm growth inhibition (MAAAGI) trial
A Wanhainen, J Unosson, K Mani, A Gottsäter… - European Journal of …, 2021 - ejves.com
Worldwide about 20 million people have an abdominal aortic aneurysm (AAA) and rupture
leads to approximately 200 000 deaths annually. To prevent rupture, early detection and …
leads to approximately 200 000 deaths annually. To prevent rupture, early detection and …