[HTML][HTML] Protocol for the Metformin Aneurysm Trial (MAT): a placebo-controlled randomised trial testing whether metformin reduces the risk of serious complications of …

J Golledge, C Arnott, J Moxon, H Monaghan, R Norman… - Trials, 2021 - Springer
Background Multiple observational studies have associated metformin prescription with
reduced progression of abdominal aortic aneurysm (AAA). The Metformin Aneurysm Trial …

[HTML][HTML] Editor's Choice–Association between metformin prescription and abdominal aortic aneurysm growth and clinical events: a systematic review and meta …

S Thanigaimani, TP Singh, J Unosson, J Phie… - European Journal of …, 2021 - Elsevier
Objective A meta-analysis of the association between metformin prescription and abdominal
aortic aneurysm (AAA) growth and events (rupture or surgical repair) was performed …

[HTML][HTML] Editor's choice–metformin prescription is associated with a reduction in the combined incidence of surgical repair and rupture related mortality in patients with …

J Golledge, DR Morris, J Pinchbeck… - European Journal of …, 2019 - Elsevier
Objectives Currently there is no drug therapy for abdominal aortic aneurysm (AAA) and most
previous investigations have focused on imaging rather than clinical outcomes. The aim of …

[HTML][HTML] Association between metformin and abdominal aortic aneurysm: A meta-analysis

W Niu, J Shao, B Yu, G Liu, R Wang, H Dong… - Frontiers in …, 2022 - frontiersin.org
Objective To systematically examine the association between metformin and abdominal
aortic aneurysm (AAA) and provide a basis for the treatment of AAA. Methods Pubmed …

[HTML][HTML] The protective effect of metformin on abdominal aortic aneurysm: a systematic review and meta-analysis

Z Yuan, Z Heng, Y Lu, J Wei, Z Cai - Frontiers in Endocrinology, 2021 - frontiersin.org
Background Type 2 diabetes mellitus (T2DM) patients have a lower risk of abdominal aortic
aneurysm (AAA) and its comorbidities, which might be associated with the usage of …

[PDF][PDF] Background and proposed design for a metformin abdominal aortic aneurysm supression trial

R Dalman, Y Lu, K Mahaffey… - Vascular & …, 2020 - assets.radcliffecardiology.com
Abdominal aortic aneurysm (AAA) may lead to rupture and death if left untreated. While
endovascular or surgical repair is generally recommended for AAA greater than 5–5.5 cm …

Association between metformin prescription and growth rates of abdominal aortic aneurysms

J Golledge, J Moxon, J Pinchbeck… - Journal of British …, 2017 - academic.oup.com
Background It has been suggested that diabetes medications, such as metformin, may have
effects that inhibit abdominal aortic aneurysm (AAA) growth. The aim of this study was to …

Association of metformin and abdominal aortic aneurysm repair outcomes

A Turowicz, J Kobecki, A Laskowska… - Annals of Vascular …, 2021 - Elsevier
Background Metformin is a commonly used drug in diabetes mellitus treatment. Recently it
has been suggested that the use of metformin on diabetes mellitus patients may lower the …

[HTML][HTML] Metformin treatment does not affect the risk of ruptured abdominal aortic aneurysms

KL Kristensen, A Pottegård, J Hallas… - Journal of vascular …, 2017 - Elsevier
Objective Diabetes counteracts formation and rupture of abdominal aortic aneurysms,
possibly through arterial matrix accumulation. Use of metformin, on the other hand, reduces …

The metformin for abdominal aortic aneurysm growth inhibition (MAAAGI) trial

A Wanhainen, J Unosson, K Mani, A Gottsäter… - European Journal of …, 2021 - ejves.com
Worldwide about 20 million people have an abdominal aortic aneurysm (AAA) and rupture
leads to approximately 200 000 deaths annually. To prevent rupture, early detection and …