Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …

Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …

The constant changes in cancer cell bioenergetics are widely known as metabolic
reprogramming. Reprogramming is a process mediated by multiple factors, including …

Dysregulation of metabolism allows tumor cells to generate needed building blocks as well
as to modulate epigenetic marks to support cancer initiation and progression. Cancer …

Metabolic and epigenetic reprogramming are characteristics of cancer cells that, in many
cases, are linked. Oncogenic signaling, diet, and tumor microenvironment each influence …

Epigenetic modifications and metabolism are two fundamental biological processes. During
tumorigenesis and cancer development both epigenetic and metabolic alterations occur and …

Cancer cells characterized by uncontrolled growth and proliferation require altered
metabolic processes to maintain this characteristic. Metabolic reprogramming is a process …

Adaptation of cellular function with the nutrient environment is essential for survival. Failure
to adapt can lead to cell death and/or disease. Indeed, energy metabolism alterations are a …

Alterations in the epigenome and metabolism affect molecular rewiring of cancer cells
facilitating cancer development and progression. Modulation of histone and DNA …

Epigenetic and metabolic alterations in cancer cells are highly intertwined. Oncogene-driven
metabolic rewiring modifies the epigenetic landscape via modulating the activities of DNA …