DNA methylation loss in late-replicating domains is linked to mitotic cell division
DNA methylation loss occurs frequently in cancer genomes, primarily within lamina-
associated, late-replicating regions termed partially methylated domains (PMDs). We …
associated, late-replicating regions termed partially methylated domains (PMDs). We …
Cell division drives DNA methylation loss in late-replicating domains in primary human cells
DNA methylation undergoes dramatic age-related changes, first described more than four
decades ago. Loss of DNA methylation within partially methylated domains (PMDs), late …
decades ago. Loss of DNA methylation within partially methylated domains (PMDs), late …
Global delay in nascent strand DNA methylation
Cytosine methylation is widespread among organisms and essential for mammalian
development. In line with early postulations of an epigenetic role in gene regulation …
development. In line with early postulations of an epigenetic role in gene regulation …
Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration
Mitotic inheritance of the DNA methylome is a challenging task for the maintenance of cell
identity. Whether DNA methylation pattern in different genomic contexts can all be faithfully …
identity. Whether DNA methylation pattern in different genomic contexts can all be faithfully …
Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains
Extensive changes in DNA methylation are common in cancer and may contribute to
oncogenesis through transcriptional silencing of tumor-suppressor genes. Genome-scale …
oncogenesis through transcriptional silencing of tumor-suppressor genes. Genome-scale …
Senescent cells harbour features of the cancer epigenome
Altered DNA methylation and associated destabilization of genome integrity and function is
a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes …
a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes …
The human placenta methylome
DI Schroeder, JD Blair, P Lott, HOK Yu… - Proceedings of the …, 2013 - National Acad Sciences
Tissue-specific DNA methylation is found at promoters, enhancers, and CpG islands but also
over larger genomic regions. In most human tissues, the vast majority of the genome is …
over larger genomic regions. In most human tissues, the vast majority of the genome is …
Increased methylation variation in epigenetic domains across cancer types
Tumor heterogeneity is a major barrier to effective cancer diagnosis and treatment. We
recently identified cancer-specific differentially DNA-methylated regions (cDMRs) in colon …
recently identified cancer-specific differentially DNA-methylated regions (cDMRs) in colon …
[HTML][HTML] Genome-wide methylation analysis of human colon cancer reveals similar hypo-and hypermethylation at conserved tissue-specific CpG island shores
Alterations in DNA methylation (DNAm) in cancer have been known for 25 years, including
hypomethylation of oncogenes and hypermethylation of tumor suppressor genes 1 …
hypomethylation of oncogenes and hypermethylation of tumor suppressor genes 1 …
A comprehensive analysis of 195 DNA methylomes reveals shared and cell-specific features of partially methylated domains
Background Partially methylated domains are extended regions in the genome exhibiting a
reduced average DNA methylation level. They cover gene-poor and transcriptionally …
reduced average DNA methylation level. They cover gene-poor and transcriptionally …