BACKGROUND It has long been thought that the factors affecting embryo and foetal
development were exclusively maternally derived; hence, if issues regarding fertility and …

Historically, less attention has been paid to paternal effects on early embryogenesis than
maternal effects. However, it is now apparent that certain male factor infertility phenotypes …

The integrity of the sperm genome and epigenome are critical for normal embryonic
development. The advent of assisted reproductive technology has led to an increased …

Recent work in the field of male fertility has yielded significant increases in our
understanding of the sperm epigenome and its potential role in embryonic development …

The scope of paternal contributions during early embryonic development has long been
considered limited. Dramatic changes in chromatin structure throughout spermatogenesis …

It has been widely held that all that fathers essentially contribute to the next generation is
half their genome. However, recent progress towards understanding biological processes …

Infertility is a devastating experience for both partners as they try to conceive. Historically,
when a couple could not conceive, the woman has carried the stigma of infertility; however …

The objective of this review was to examine the role of the various spermatozoal
components suspected of actively participating in early human development. The …

Having been debated for many years, the presence and role of spermatozoal RNAs is
resolving, and their contribution to development is now appreciated. Data from different …

During fertilization, spermatozoa contribute genetic and epigenetic factors that affect early
embryogenesis. Genetic factors include a haploid genome with intact coding regions and …