Primary cilia are implicated in the pathogenesis of autosomal-dominant polycystic kidney
disease (ADPKD), which results from defects in polycystin-1 (PC1), but the function of PC1 …

Several proteins implicated in the pathogenesis of polycystic kidney disease (PKD) localize
to cilia. Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw …

The external surfaces of the human body, as well as its internal organs, constantly
experience different kinds of mechanical stimulations. For example, tubular epithelial cells of …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by formation of
renal cysts that destroy the kidney. Mutations in PKD1 and PKD2, encoding polycystins-1 …

Autosomal-dominant polycystic kidney disease (ADPKD) is a disease of defective tissue
homeostasis resulting in active remodeling of nephrons and bile ducts to form fluid-filled …

Primary cilia play a key role in the pathogenesis of autosomal dominant polycystic kidney
disease (ADPKD). The affected proteins, polycystin-1 (PC1) and polycystin-2 (PC2), interact …

Polycystic kidney disease (PKD), comprising autosomal dominant polycystic kidney disease
(ADPKD) and autosomal recessive polycystic kidney d isease (ARPKD), is characterized by …

Polycystin-2 functions as a cation-permeable transient receptor potential ion channel in
kidney epithelial cells and when mutated results in human autosomal dominant polycystic …

Autosomal dominant polycystic kidney disease (ADPKD) gene products polycystin-1 (PC1)
and polycystin-2 (PC2) colocalize in the apical monocilia of renal epithelial cells. Mouse and …

Defects in the PKD1 and PKD2 genes cause autosomal dominant polycystic kidney disease
(PKD) in~ 1 in 1000 adults worldwide. These genes encode polycystin-1 and polycystin-2 …