Objectives We aimed to evaluate 1) whether sedation analgesia (SA) used during
therapeutic hypothermia (TH) is efficient to support the well-being of neonates with hypoxic …

Background Newborn infants undergoing therapeutic hypothermia (TH) are exposed to
multiple painful and stressful procedures. The aim of this systematic review was to assess …

Objectives To evaluate the use of sedatives and analgesics during therapeutic hypothermia
in encephalopathic neonates and assess associations between medication exposure and …

Background Therapeutic hypothermia (TH) is a widely practiced neuroprotective strategy for
neonates with hypoxic-ischemic encephalopathy. Induced hypothermia is associated with …

Background Neonates that have been subjected to perinatal asphyxia and fulfill criteria for
therapeutic hypothermia are cooled to 33.5° C for 72 h. There is no consensus regarding …

Although none of the major cooling trials mandated routine pre-emptive sedation, anecdotal
evidence suggests that opioids are widely used during neonatal cooling therapy. We …

Perinatal asphyxia is a major contributor to neonatal death in term‐born infants. Hypoxic‐
ischaemic encephalopathy (HIE) is the most important asphyxia‐related complication …

Aim Heart rate (HR) plays an important role in the assessment of stress during therapeutic
hypothermia (TH) for neonatal encephalopathy; we aimed to quantify the effect on HR of …

Introduction Therapeutic hypothermia is the standard care for asphyxiated newborns.
Discomfort and pain during treatment are common and may affect therapeutic efficacy of …

Background Newborn infants affected by hypoxic‐ischemic encephalopathy (HIE) undergo
therapeutic hypothermia. As this treatment seems to be associated with pain, and intensive …