Embryonic development in mammals is distinct from that in other vertebrates because it
depends on a small number of imprinted genes that are specifically expressed from either …

Genomic imprinting confers a developmental asymmetry on the parental genomes, through
epigenetic modifications in the germ line and embryo. These heritable modifications …

Phenotypic anomalies have been observed among animals cloned from somatic cells,
putatively caused by epigenetic alterations, especially those of imprinted genes (1) …

Genomic imprinting results in preferential expression of the paternal or maternal allele of
certain genes. We have performed a genome-wide characterization of imprinting in the …

THE paternal and maternal genomes are not equivalent and both are required for
mammalian development1, 2. The difference between the parental genomes is believed to …

Mouse embryogenesis relies on the presence of both the maternal and the paternal genome
for development to term1, 2. It has been proposed that specific modifications are imprinted …

Imprinted genes are expressed differently depending on whether they are carried by a
chromosome of maternal or paternal origin. Correct imprinting is established by germline …

DNA methylation is a major epigenetic modification of the genome that regulates crucial
aspects of its function. Genomic methylation patterns in somatic differentiated cells are …

), came as quite a surprise and forced classical Mendelian genetics to undergo a number of
revisions. The discovery of imprinting also presents us with a genetic paradox: by silencing …

Genomic imprinting refers to the process whereby specific genes are differentially marked
during parental gametogenesis, resulting in the differential expression of these genes in the …